Prenatal exposure to organochlorine compounds and lung function during childhood.
Birth cohort
Children
Dichlorodiphenyldichloroethylene
Lung function
Organochlorine compounds
Prenatal exposure
Journal
Environment international
ISSN: 1873-6750
Titre abrégé: Environ Int
Pays: Netherlands
ID NLM: 7807270
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
10
04
2019
revised:
05
07
2019
accepted:
22
07
2019
pubmed:
31
7
2019
medline:
25
2
2020
entrez:
31
7
2019
Statut:
ppublish
Résumé
Prenatal exposure to organochlorine compounds (OCs) can increase the risk of reported respiratory symptoms in children. It remains unclear whether these compounds can also impact on lung function. We assessed the association between prenatal exposure to OCs and lung function during childhood. We included 1308 mother-child pairs enrolled in a prospective cohort study. Prenatal concentrations of p,p'-dichlorodiphenyltrichloroethane [p,p'-DDT], p,p'-dichlorodiphenyldichloroethylene [p,p'-DDE], hexachlorobenzene [HCB], and seven polychlorinated biphenyls [PCBs] were measured in cord blood. Spirometry was performed in the offspring at ages 4 (n = 636) and 7 years (n = 1192). More than 80% of samples presented quantifiable levels of p,p'-DDE, HCB, PCB-138, PCB-153, and PCB-180; p,p'-DDE was the compound with the highest median concentrations. At 4 years, prenatal p,p'-DDE exposure was associated with a decrease in forced expiratory volume in 1 s (FEV Prenatal exposure to p,p'-DDE may decrease lung function during childhood, especially FEV
Identifiants
pubmed: 31362153
pii: S0160-4120(19)31177-8
doi: 10.1016/j.envint.2019.105049
pii:
doi:
Substances chimiques
Hydrocarbons, Chlorinated
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
105049Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.