Functional aging in health and heart failure: the COmPLETE Study.
Aging
Exercise
Fitness
Heart failure
Vascular function
Journal
BMC cardiovascular disorders
ISSN: 1471-2261
Titre abrégé: BMC Cardiovasc Disord
Pays: England
ID NLM: 100968539
Informations de publication
Date de publication:
30 07 2019
30 07 2019
Historique:
received:
29
05
2019
accepted:
18
07
2019
entrez:
1
8
2019
pubmed:
1
8
2019
medline:
19
5
2020
Statut:
epublish
Résumé
Cardiovascular (CV) diseases including heart failure are the leading causes of morbidity, with age being the primary risk factor. The combination of age-related organic functional impairment and reduced physical fitness can drastically impact an individual's healthspan. One's lifespan can potentially be prolonged by the preservation or improvement of physical fitness. However, it remains unclear as to which biomarkers are most suitable for distinguishing between healthy aging and the impaired organ function associated with heart failure. Therefore, a comprehensive assessment of the components of physical fitness and CV function will be performed to identify the most important factors contributing to aging in relation to both health and disease. This cross-sectional investigation will consist of two parts: COmPLETE-Health (C-Health) and COmPLETE-Heart (C-Heart). C-Health will examine the aging trajectories of physical fitness components and CV properties in a healthy population sample aged between 20 and 100 years (n = 490). Separately, C-Heart will assess the same markers in patients at different stages of chronic heart failure (n = 80). The primary outcome to determine the difference between C-Health and C-Heart will be cardiorespiratory fitness as measured by cardiopulmonary exercise testing on a bicycle ergometer. Secondary outcomes will include walking speed, balance, isometric strength, peak power, and handgrip strength. Physical activity as a behavioural component will be assessed objectively via accelerometry. Further, CV assessments will include pulse wave velocity; retinal, arterial, and venous diameters; brachial and retinal arterial endothelial function; carotid intima-media thickness; and systolic and diastolic function. The health distances for C-Health and C-Heart will be calculated using the methodology based on statistical (Mahalanobis) distance applied to measurements of quantitative biomarkers. This research seeks to identify physical fitness and CV biomarkers that best resemble underlying CV risk with age. Further, it will examine which physical fitness markers are impaired most in heart failure. The presented integrative approach could define new recommendations for diagnostic guidance in aging. Ultimately, this study is expected to offer a better understanding of which functional characteristics should be specifically targeted in primary and secondary prevention to achieve an optimal healthspan.
Sections du résumé
BACKGROUND
Cardiovascular (CV) diseases including heart failure are the leading causes of morbidity, with age being the primary risk factor. The combination of age-related organic functional impairment and reduced physical fitness can drastically impact an individual's healthspan. One's lifespan can potentially be prolonged by the preservation or improvement of physical fitness. However, it remains unclear as to which biomarkers are most suitable for distinguishing between healthy aging and the impaired organ function associated with heart failure. Therefore, a comprehensive assessment of the components of physical fitness and CV function will be performed to identify the most important factors contributing to aging in relation to both health and disease.
METHODS
This cross-sectional investigation will consist of two parts: COmPLETE-Health (C-Health) and COmPLETE-Heart (C-Heart). C-Health will examine the aging trajectories of physical fitness components and CV properties in a healthy population sample aged between 20 and 100 years (n = 490). Separately, C-Heart will assess the same markers in patients at different stages of chronic heart failure (n = 80). The primary outcome to determine the difference between C-Health and C-Heart will be cardiorespiratory fitness as measured by cardiopulmonary exercise testing on a bicycle ergometer. Secondary outcomes will include walking speed, balance, isometric strength, peak power, and handgrip strength. Physical activity as a behavioural component will be assessed objectively via accelerometry. Further, CV assessments will include pulse wave velocity; retinal, arterial, and venous diameters; brachial and retinal arterial endothelial function; carotid intima-media thickness; and systolic and diastolic function. The health distances for C-Health and C-Heart will be calculated using the methodology based on statistical (Mahalanobis) distance applied to measurements of quantitative biomarkers.
DISCUSSION
This research seeks to identify physical fitness and CV biomarkers that best resemble underlying CV risk with age. Further, it will examine which physical fitness markers are impaired most in heart failure. The presented integrative approach could define new recommendations for diagnostic guidance in aging. Ultimately, this study is expected to offer a better understanding of which functional characteristics should be specifically targeted in primary and secondary prevention to achieve an optimal healthspan.
Identifiants
pubmed: 31362698
doi: 10.1186/s12872-019-1164-6
pii: 10.1186/s12872-019-1164-6
pmc: PMC6664502
doi:
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
180Subventions
Organisme : NIA NIH HHS
ID : P30 AG034424
Pays : United States
Organisme : NICHD NIH HHS
ID : R03 HD050374
Pays : United States
Références
Atherosclerosis. 2011 Jun;216(2):433-9
pubmed: 21392768
Am J Respir Crit Care Med. 2003 Jan 15;167(2):211-77
pubmed: 12524257
Am Heart J. 2018 Aug;202:116-126
pubmed: 29933148
J Sports Sci Med. 2007 Dec 01;6(4):477-83
pubmed: 24149481
Ultrasound Med Biol. 2012 Aug;38(8):1440-50
pubmed: 22749339
J Aging Phys Act. 2015 Jul;23(3):352-60
pubmed: 25007824
J Physiol. 2016 Apr 15;594(8):2001-24
pubmed: 25639909
J Diabetes Res. 2017;2017:2303467
pubmed: 28848767
Mech Ageing Dev. 2016 Jun;156:42-54
pubmed: 27138087
Circ Heart Fail. 2017 Feb;10(2):
pubmed: 28159826
BMC Musculoskelet Disord. 2015 Mar 18;16:60
pubmed: 25887598
Arch Ophthalmol. 2006 Jan;124(1):87-94
pubmed: 16401789
J Electrocardiol. 2014 Jul-Aug;47(4):505-11
pubmed: 24795285
Hypertension. 2001 Dec 1;38(6):1451-5
pubmed: 11751734
Arch Intern Med. 2006 Nov 27;166(21):2388-94
pubmed: 17130394
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2005 Dec;48(12):1330-7
pubmed: 16270186
J Am Heart Assoc. 2016 Oct 26;5(11):
pubmed: 27912210
Trends Endocrinol Metab. 2006 Sep;17(7):262-8
pubmed: 16890449
Curr Heart Fail Rep. 2017 Dec;14(6):489-497
pubmed: 28940089
Hypertension. 2017 Feb;69(2):267-274
pubmed: 27993954
Atherosclerosis. 2015 Oct;242(2):433-42
pubmed: 26291496
Aging (Albany NY). 2012 Aug;4(8):547-52
pubmed: 22915707
PLoS One. 2014 Nov 26;9(11):e113884
pubmed: 25426954
Lancet. 2016 Oct 8;388(10053):1545-1602
pubmed: 27733282
Can J Appl Physiol. 2005 Oct;30(5):554-75
pubmed: 16293904
Eur Heart J. 2013 Feb;34(7):512-9
pubmed: 23178647
Phys Ther. 2005 Oct;85(10):1008-119
pubmed: 16180950
Arch Phys Med Rehabil. 1991 Apr;72(5):280-3
pubmed: 2009042
Lancet. 2015 Aug 8;386(9993):533-40
pubmed: 26049253
J Appl Physiol (1985). 1997 Jul;83(1):160-5
pubmed: 9216959
Atherosclerosis. 2013 Dec;231(2):448-55
pubmed: 24267265
Scand J Clin Lab Invest. 2014 Mar;74(2):155-62
pubmed: 24329101
Mayo Clin Proc. 2015 Mar;90(3):346-55
pubmed: 25744114
Eur Heart J. 2016 Jul 14;37(27):2129-2200
pubmed: 27206819
Heart Fail Rev. 2012 Sep;17(4-5):545-54
pubmed: 21809160
Hypertension. 2006 Feb;47(2):189-94
pubmed: 16380526
ESC Heart Fail. 2017 Nov;4(4):492-498
pubmed: 29154428
J Am Med Dir Assoc. 2011 May;12(4):249-56
pubmed: 21527165
Am J Cardiol. 2005 Mar 15;95(6):734-41
pubmed: 15757599
Nutr Res. 2012 Jul;32(7):479-85
pubmed: 22901555
Ophthalmology. 2004 Jun;111(6):1183-90
pubmed: 15177969
J Gerontol A Biol Sci Med Sci. 2014 May;69(5):584-90
pubmed: 24737561
Lancet. 2017 Sep 16;390(10100):1211-1259
pubmed: 28919117
J Hand Surg Am. 2002 Sep;27(5):897-901
pubmed: 12239682
J Health Soc Behav. 1983 Dec;24(4):385-96
pubmed: 6668417
Lancet. 2012 Jul 7;380(9836):59-64
pubmed: 22770457
Front Public Health. 2016 Jan 25;4:3
pubmed: 26835445
Arch Gerontol Geriatr. 2015 Sep-Oct;61(2):161-7
pubmed: 26164372
J Am Coll Cardiol. 1997 Dec;30(7):1758-64
pubmed: 9385904
Sensors (Basel). 2013 Dec 27;14(1):443-57
pubmed: 24379049
Stat Methods Med Res. 2007 Jun;16(3):219-42
pubmed: 17621469
Med Sci Sports Exerc. 2011 Jun;43(6):1085-93
pubmed: 21088628
Am J Epidemiol. 1998 Apr 15;147(8):755-63
pubmed: 9554417
Circ Heart Fail. 2009 Mar;2(2):113-20
pubmed: 19808326
Blood Press Monit. 2015 Oct;20(5):273-9
pubmed: 26065840
J Am Soc Echocardiogr. 2005 Dec;18(12):1440-63
pubmed: 16376782
Math Biosci. 2007 Aug;208(2):538-51
pubmed: 17300818
J Mot Behav. 2012;44(5):329-40
pubmed: 22934664
Circulation. 2016 Nov 1;134(18):1339-1352
pubmed: 27678264
JAMA. 1988 Feb 26;259(8):1190-3
pubmed: 3339820
Lancet. 2016 Sep 24;388(10051):1302-10
pubmed: 27475271
Sleep. 2011 May 01;34(5):601-8
pubmed: 21532953
Eur J Appl Physiol. 2014 Jan;114(1):29-39
pubmed: 24122149
N Engl J Med. 1980 Jul 17;303(3):130-5
pubmed: 7383070
Circulation. 2005 Aug 2;112(5):674-82
pubmed: 16043637
Age Ageing. 2015 Sep;44(5):790-5
pubmed: 26163682
J Gerontol A Biol Sci Med Sci. 2006 Jan;61(1):72-7
pubmed: 16456196
J Card Fail. 2016 Jul;22(7):492-7
pubmed: 26844765
J Am Geriatr Soc. 2005 Sep;53(9):1618-22
pubmed: 16137297
Med Sci Sports Exerc. 2010 Sep;42(9):1619-24
pubmed: 20195176
Acta Ophthalmol. 2010 Nov;88(7):717-22
pubmed: 19681764
Age Ageing. 2010 Jul;39(4):412-23
pubmed: 20392703
Ophthalmology. 1999 Dec;106(12):2269-80
pubmed: 10599656
Age (Dordr). 2006 Dec;28(4):363-374
pubmed: 17895962
Atherosclerosis. 2015 Aug;241(2):507-32
pubmed: 26117398
J Aging Res. 2012;2012:386387
pubmed: 22966457
J Nutr Health Aging. 2010 Aug;14(7):595-600
pubmed: 20818476
JAMA. 2011 Jan 5;305(1):50-8
pubmed: 21205966
J Biol Rhythms. 2003 Feb;18(1):80-90
pubmed: 12568247
Metabolism. 2011 Dec;60(12):1736-40
pubmed: 21700302
JACC Heart Fail. 2016 Apr;4(4):289-98
pubmed: 26970831
J Gerontol A Biol Sci Med Sci. 2009 Feb;64(2):209-12
pubmed: 19196900
Public Health Rep. 1985 Mar-Apr;100(2):126-31
pubmed: 3920711
Med Sci Sports Exerc. 2001 Jun;33(6 Suppl):S379-99; discussion S419-20
pubmed: 11427763
Circulation. 2003 Jan 7;107(1):139-46
pubmed: 12515756
J Gerontol A Biol Sci Med Sci. 2019 Mar 14;74(4):462-468
pubmed: 29939206
Eur Heart J. 2007 Aug;28(16):1984-92
pubmed: 17626032
Eur J Heart Fail. 2005 Jun;7(4):498-504
pubmed: 15921786
Lancet. 2017 Apr 1;389(10076):1323-1335
pubmed: 28236464
Eur Heart J. 2013 Dec;34(45):3501-7
pubmed: 23821401
Ann N Y Acad Sci. 2007 Apr;1100:1-13
pubmed: 17460161
Am J Epidemiol. 2009 Dec 1;170(11):1323-32
pubmed: 19884126
J Gerontol A Biol Sci Med Sci. 2013 Aug;68(8):968-75
pubmed: 23525477
J Am Coll Cardiol. 2015 Mar 24;65(11):1065-74
pubmed: 25790876
Arch Gerontol Geriatr. 2012 Sep-Oct;55(2):474-9
pubmed: 22564361
Med Sci Sports Exerc. 2015 Oct;47(10):2129-39
pubmed: 25785929
BMJ Open Sport Exerc Med. 2017 May 8;3(1):e000206
pubmed: 28761703
Circulation. 2018 Jan 9;137(2):148-161
pubmed: 28993402
Am J Cardiol. 2015 Mar 15;115(6):797-801
pubmed: 25655868
Int J Behav Nutr Phys Act. 2016 May 23;13:61
pubmed: 27215626
Scand J Med Sci Sports. 2011 Dec;21(6):e168-75
pubmed: 20874860
Gait Posture. 2013 Apr;37(4):500-5
pubmed: 23018028
J Hypertens. 2018 Mar;36(3):560-568
pubmed: 29084082
Aging Clin Exp Res. 2016 Jun;28(3):393-405
pubmed: 26210370
Hypertension. 2003 Oct;42(4):534-41
pubmed: 12939235
Science. 2014 Oct 31;346(6209):587-91
pubmed: 25359967
Am J Physiol Heart Circ Physiol. 2009 Sep;297(3):H1109-16
pubmed: 19633208
Hypertension. 2017 Dec;70(6):1157-1164
pubmed: 29061725
Mech Ageing Dev. 2013 Mar;134(3-4):110-7
pubmed: 23376244
J Am Coll Cardiol. 2014 Feb 25;63(7):636-646
pubmed: 24239664
Eur Heart J. 2016 Aug 01;37(29):2300-6
pubmed: 26916798
PLoS One. 2017 Feb 1;12(2):e0169649
pubmed: 28146576
PLoS One. 2015 Jun 02;10(6):e0128991
pubmed: 26035590
Front Physiol. 2018 Feb 21;9:116
pubmed: 29515458
J Gerontol A Biol Sci Med Sci. 2002 Oct;57(10):B359-65
pubmed: 12242311
Eur Heart J. 2018 Jan 1;39(1):47-56
pubmed: 29069316
Eur J Appl Physiol. 2016 Jun;116(6):1091-116
pubmed: 26941023
N Am Actuar J. 2016;20(3):201-232
pubmed: 27773987
Neurology. 2006 May 9;66(9):1339-43
pubmed: 16682664
Circulation. 1993 Oct;88(4 Pt 1):1456-62
pubmed: 8403292
Am J Physiol Heart Circ Physiol. 2014 May;306(9):H1364-70
pubmed: 24658015
Sports Med. 2008;38(6):441-7
pubmed: 18489192
Mech Ageing Dev. 2011 Mar;132(3):93-102
pubmed: 21262255
J Musculoskelet Neuronal Interact. 2006 Apr-Jun;6(2):167-73
pubmed: 16849828
Circulation. 2017 Mar 7;135(10):e146-e603
pubmed: 28122885
Am J Phys Med Rehabil. 2007 Nov;86(11):893-900
pubmed: 17873824
J Biomech. 2010 Nov 16;43(15):2999-3006
pubmed: 20656291
Physiol Rev. 2017 Apr;97(2):495-528
pubmed: 28151424
BMC Med Res Methodol. 2011 Jun 20;11:94
pubmed: 21689447
JAMA. 2009 May 20;301(19):2024-35
pubmed: 19454641
Int J Sports Med. 1982 Aug;3(3):153-8
pubmed: 7129724
Am Heart J. 2017 Feb;184:55-61
pubmed: 27892887
Eur Heart J. 2006 Nov;27(21):2580-7
pubmed: 16952925