ErbB3-binding protein 1 (EBP1) represses HNF4α-mediated transcription and insulin secretion in pancreatic β-cells.

Adaptor Proteins, Signal Transducing / metabolism Carrier Proteins / metabolism DNA-Binding Proteins / metabolism Diabetes Mellitus, Type 2 / metabolism Gene Expression Regulation / genetics HeLa Cells Hepatocyte Nuclear Factor 4 / metabolism Humans Insulin / metabolism Insulin Secretion / genetics Insulin-Secreting Cells / metabolism Promoter Regions, Genetic / genetics Protein Binding / physiology RNA-Binding Proteins / metabolism Transcription Factors
EBP1 HNF4alpha corepressor diabetes gene regulation insulin secretion metabolic regulation nuclear receptor pancreatic beta-cell protein complex protein–protein interaction

Journal

The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R

Informations de publication

Date de publication:
20 09 2019
Historique:
received: 30 05 2019
revised: 18 07 2019
pubmed: 1 8 2019
medline: 13 5 2020
entrez: 1 8 2019
Statut: ppublish

Résumé

HNF4α (hepatocyte nuclear factor 4α) is one of the master regulators of pancreatic β-cell development and function, and mutations in the

Identifiants

DOI: 10.1074/jbc.RA119.009558 PMID: 31362984 PMC: PMC6755798
pubmed: 31362984
pii: S0021-9258(20)32084-6
doi: 10.1074/jbc.RA119.009558
pmc: PMC6755798
doi:

Substances chimiques

Adaptor Proteins, Signal Transducing 0
Carrier Proteins 0
DNA-Binding Proteins 0
HNF4A protein, human 0
Hepatocyte Nuclear Factor 4 0
Insulin 0
PA2G4 protein, human 0
RNA-Binding Proteins 0
Transcription Factors 0

Banques de données

PDB
['1M7W', '1PZL', '3FS1', '6CHT']

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

13983-13994

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK052913
Pays : United States

Informations de copyright

© 2019 Han et al.

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Auteurs

Eun Hee Han (EH)

Section of Structural Biology, Hormel Institute, University of Minnesota, Austin, Minnesota 55912.
Drug & Disease Target Group, Division of Life Science, Korea Basic Science Institute, Cheongju 28119, Republic of Korea.

Puja Singh (P)

Section of Structural Biology, Hormel Institute, University of Minnesota, Austin, Minnesota 55912.

In-Kyu Lee (IK)

Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu 41944, Republic of Korea.

Raul Urrutia (R)

Genomic Sciences and Precision Medicine Center, Medical College of Wisconsin, Division of Research, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin 53226.

Young-In Chi (YI)

Section of Structural Biology, Hormel Institute, University of Minnesota, Austin, Minnesota 55912 ychi@mcw.edu.
Genomic Sciences and Precision Medicine Center, Medical College of Wisconsin, Division of Research, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin 53226.
ORCID: 0000-0001-9220-9511

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines adaptatrices de la transduction du signal › ErbB3-binding protein 1 (EBP1) represses...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › ErbB3-binding protein 1 (EBP1) represses...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › ErbB3-binding protein 1 (EBP1) represses...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète de type 2 › ErbB3-binding protein 1 (EBP1) represses...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › ErbB3-binding protein 1 (EBP1) represses...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HeLa › ErbB3-binding protein 1 (EBP1) represses...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs nucléaires hépatocytaires › Facteur nucléaire hépatocytaire HNF-4 › ErbB3-binding protein 1 (EBP1) represses...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › ErbB3-binding protein 1 (EBP1) represses...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones pancréatiques › Insulines › Insuline › ErbB3-binding protein 1 (EBP1) represses...
questionsmedicales.fr › Phénomènes physiologiques › Sécrétion d'insuline › ErbB3-binding protein 1 (EBP1) represses...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules entéroendocrines › Cellules à insuline › ErbB3-binding protein 1 (EBP1) represses...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Éléments de régulation transcriptionnelle › Régions promotrices (génétique) › ErbB3-binding protein 1 (EBP1) represses...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › ErbB3-binding protein 1 (EBP1) represses...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › ErbB3-binding protein 1 (EBP1) represses...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › ErbB3-binding protein 1 (EBP1) represses...