Mice Fed an Obesogenic Western Diet, Administered Antibiotics, and Subjected to a Sterile Surgical Procedure Develop Lethal Septicemia with Multidrug-Resistant Pathobionts.
Animals
Anti-Bacterial Agents
/ therapeutic use
C-Reactive Protein
/ metabolism
Diet, Western
/ adverse effects
Drug Resistance, Bacterial
/ genetics
Gastrointestinal Microbiome
/ drug effects
In Situ Nick-End Labeling
Interleukin-6
/ blood
Male
Mice
Mice, Inbred C57BL
RNA, Ribosomal, 16S
/ genetics
Sepsis
/ blood
Western diet
gut microbiome
gut-derived sepsis
pathobionts
surgery
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
30 07 2019
30 07 2019
Historique:
entrez:
1
8
2019
pubmed:
1
8
2019
medline:
28
4
2020
Statut:
epublish
Résumé
Despite antibiotics and sterile technique, postoperative infections remain a real and present danger to patients. Recent estimates suggest that 50% of the pathogens associated with postoperative infections have become resistant to the standard antibiotics used for prophylaxis. Risk factors identified in such cases include obesity and antibiotic exposure. To study the combined effect of obesity and antibiotic exposure on postoperative infection, mice were allowed to gain weight on an obesogenic Western-type diet (WD), administered antibiotics and then subjected to an otherwise recoverable sterile surgical injury (30% hepatectomy). The feeding of a WD alone resulted in a major imbalance of the cecal microbiota characterized by a decrease in diversity, loss of
Identifiants
pubmed: 31363025
pii: mBio.00903-19
doi: 10.1128/mBio.00903-19
pmc: PMC6667615
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Interleukin-6
0
RNA, Ribosomal, 16S
0
C-Reactive Protein
9007-41-4
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM062344
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019 Hyoju et al.
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