Long Noncoding RNA,

Cell Line, Tumor Cell Proliferation / genetics Cyclin-Dependent Kinase Inhibitor p15 / genetics Cyclin-Dependent Kinase Inhibitor p16 / genetics G1 Phase Cell Cycle Checkpoints / genetics Gene Expression Regulation, Neoplastic / genetics Humans RNA, Long Noncoding / genetics RNA, Messenger / genetics RNA, Small Interfering / genetics Squamous Cell Carcinoma of Head and Neck / genetics
ANRIL CDK inhibitor cell cycle head and neck squamous cell carcinoma

Journal

Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988

Informations de publication

Date de publication:
Aug 2019
Historique:
received: 14 05 2019
revised: 17 06 2019
accepted: 18 06 2019
entrez: 2 8 2019
pubmed: 2 8 2019
medline: 8 8 2019
Statut: ppublish

Résumé

ANRIL is a long noncoding RNA located on INK4 locus, which encodes p15 and p16 that cause G Cells were transfected with siRNA oligonucleotides targeting ANRIL. Transfected cells were subjected to cell-cycle and quantitative reverse transcription-polymerase chain reaction (qRT-PCR) analysis. Depletion of ANRIL increased p15 mRNA in FaDu cells, and p15 and p16 mRNA in CAL27 cells and inhibited proliferation of these cells. Cell cycle analysis showed that depletion of ANRIL caused arrest at the G ANRIL promotes G

Sections du résumé

BACKGROUND/AIM OBJECTIVE
ANRIL is a long noncoding RNA located on INK4 locus, which encodes p15 and p16 that cause G
MATERIALS AND METHODS METHODS
Cells were transfected with siRNA oligonucleotides targeting ANRIL. Transfected cells were subjected to cell-cycle and quantitative reverse transcription-polymerase chain reaction (qRT-PCR) analysis.
RESULTS RESULTS
Depletion of ANRIL increased p15 mRNA in FaDu cells, and p15 and p16 mRNA in CAL27 cells and inhibited proliferation of these cells. Cell cycle analysis showed that depletion of ANRIL caused arrest at the G
CONCLUSION CONCLUSIONS
ANRIL promotes G

Identifiants

DOI: 10.21873/anticanres.13564 PMID: 31366490
pubmed: 31366490
pii: 39/8/4073
doi: 10.21873/anticanres.13564
doi:

Substances chimiques

CDKN2B antisense RNA, human 0
Cyclin-Dependent Kinase Inhibitor p15 0
Cyclin-Dependent Kinase Inhibitor p16 0
RNA, Long Noncoding 0
RNA, Messenger 0
RNA, Small Interfering 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

4073-4077

Informations de copyright

Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Auteurs

Natsumi Matsunaga (N)

Graduate School of Humanity-Oriented Science and Engineering, Kindai University, Fukuoka, Japan.

Takahiro Wakasaki (T)

Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Ryuji Yasumatsu (R)

Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Yojiro Kotake (Y)

Graduate School of Humanity-Oriented Science and Engineering, Kindai University, Fukuoka, Japan ykotake@fuk.kindai.ac.jp.
Department of Biological and Environmental Chemistry, Faculty of Humanity-Oriented Science and Engineering, Kindai University, Fukuoka, Japan.

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Long Noncoding RNA,
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Long Noncoding RNA,
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines suppresseurs de tumeurs › Protéines inhibitrices des kinases cyclines-dépendantes › Inhibiteur p15 de kinase cycline-dépendante › Long Noncoding RNA,
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines suppresseurs de tumeurs › Protéines inhibitrices des kinases cyclines-dépendantes › Inhibiteur p16 de kinase cycline-dépendante › Long Noncoding RNA,
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Cycle cellulaire › Interphase › Phase G1 › Points de contrôle de la phase G1 du cycle cellulaire › Long Noncoding RNA,
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › Long Noncoding RNA,
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Long Noncoding RNA,
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › ARN long non codant › Long Noncoding RNA,
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › Long Noncoding RNA,
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › Petit ARN interférent › Long Noncoding RNA,
questionsmedicales.fr › Tumeurs › Tumeurs par siège › Tumeurs de la tête et du cou › Carcinome épidermoïde de la tête et du cou › Long Noncoding RNA,