Clinical and Prognostic Significance of Neoplastic Spindle Cells in Gallbladder Cancer.
Adult
Aged
Biomarkers, Tumor
/ blood
CA-19-9 Antigen
/ blood
Epithelial Cells
/ pathology
Epithelial-Mesenchymal Transition
/ genetics
Female
Gallbladder Neoplasms
/ blood
Humans
Kaplan-Meier Estimate
Lymphatic Metastasis
Male
Margins of Excision
Middle Aged
Neoplasm Invasiveness
/ genetics
Prognosis
Neoplastic spindle cells
epithelial–mesenchymal transition
gallbladder cancer
Journal
Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
received:
23
05
2019
revised:
20
06
2019
accepted:
21
06
2019
entrez:
2
8
2019
pubmed:
2
8
2019
medline:
7
8
2019
Statut:
ppublish
Résumé
Neoplastic spindle cells (NSCs) are believed to play a role in cancer invasion and metastasis, as well as in poor prognosis. The clinicopathological characteristics and prognostic relevance of NSCs was investigated in gallbladder cancer. Specimens were obtained from 62 patients with gallbladder cancer who underwent surgery. The emergence of NSCs and their correlation with clinicopathological factors, prognosis, and EMT markers was evaluated. The NSC grade correlated with tumor size, preoperative CA19-9, surgical margin, the degree of differentiation, the depth of invasion, lymph node metastasis, lymphatic invasion, vascular invasion, and perineural invasion. Multivariate analysis of overall survival showed that NSCs were an independent prognostic factor. A correlation between NSCs and EMT was also suggested. NSCs are an independent prognostic factor for patients with postoperative gallbladder cancer, which also suggests a correlation between NSCs and EMT.
Sections du résumé
BACKGROUND/AIM
OBJECTIVE
Neoplastic spindle cells (NSCs) are believed to play a role in cancer invasion and metastasis, as well as in poor prognosis. The clinicopathological characteristics and prognostic relevance of NSCs was investigated in gallbladder cancer.
MATERIALS AND METHODS
METHODS
Specimens were obtained from 62 patients with gallbladder cancer who underwent surgery. The emergence of NSCs and their correlation with clinicopathological factors, prognosis, and EMT markers was evaluated.
RESULTS
RESULTS
The NSC grade correlated with tumor size, preoperative CA19-9, surgical margin, the degree of differentiation, the depth of invasion, lymph node metastasis, lymphatic invasion, vascular invasion, and perineural invasion. Multivariate analysis of overall survival showed that NSCs were an independent prognostic factor. A correlation between NSCs and EMT was also suggested.
CONCLUSION
CONCLUSIONS
NSCs are an independent prognostic factor for patients with postoperative gallbladder cancer, which also suggests a correlation between NSCs and EMT.
Identifiants
pubmed: 31366560
pii: 39/8/4561
doi: 10.21873/anticanres.13634
doi:
Substances chimiques
Biomarkers, Tumor
0
CA-19-9 Antigen
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4561-4568Informations de copyright
Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.