Anti-PCSK9 antibodies inhibit pro-atherogenic mechanisms in APOE*3Leiden.CETP mice.
Animals
Antibodies, Monoclonal
/ physiology
Apolipoproteins E
/ metabolism
Atherosclerosis
/ drug therapy
Cholesterol
/ metabolism
Cholesterol, LDL
/ metabolism
Endothelial Progenitor Cells
/ drug effects
Humans
Hypolipidemic Agents
/ pharmacology
Inflammation
/ metabolism
Lectins
/ metabolism
Macrophages
/ drug effects
Mice
Plaque, Atherosclerotic
/ drug therapy
Proprotein Convertase 9
/ metabolism
Up-Regulation
/ drug effects
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
31 07 2019
31 07 2019
Historique:
received:
08
02
2019
accepted:
09
07
2019
entrez:
2
8
2019
pubmed:
2
8
2019
medline:
21
10
2020
Statut:
epublish
Résumé
LDL-cholesterol (LDL-C) is a causal pathogenic factor in atherosclerosis. Monoclonal anti-proprotein convertase subtilisin/kexin type 9 (PCSK9) neutralizing antibodies are novel potent LDL-lowering drugs which reduce cardiovascular events. To characterize their effect on atherogenesis, APOE*3Leiden.CETP mice were fed a high cholesterol/high fat diet (WTD) or normal chow (NC) for 18 weeks. Mice on WTD were injected with the human anti-PCSK9 antibody mAb1 (PL-45134, 10 mg*kg
Identifiants
pubmed: 31366894
doi: 10.1038/s41598-019-47242-0
pii: 10.1038/s41598-019-47242-0
pmc: PMC6668462
doi:
Substances chimiques
Antibodies, Monoclonal
0
Apolipoproteins E
0
Cholesterol, LDL
0
Hypolipidemic Agents
0
Lectins
0
Cholesterol
97C5T2UQ7J
Pcsk9 protein, mouse
EC 3.4.21.-
Proprotein Convertase 9
EC 3.4.21.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
11079Références
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