Peroxide-Induced Oxidative Modification of Hemoglobin.
Journal
Doklady. Biochemistry and biophysics
ISSN: 1608-3091
Titre abrégé: Dokl Biochem Biophys
Pays: United States
ID NLM: 101126895
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
23
11
2018
entrez:
2
8
2019
pubmed:
2
8
2019
medline:
30
8
2019
Statut:
ppublish
Résumé
The oxidative modification of human hemoglobin (Hb) treated with hydrogen peroxide was investigated. Using the mass spectrometry method, the oxidized amino acid residues of the hemoglobin molecule were detected: αTrp14, αTyr24, αArg31, αMet32, αTyr42, αHis45, αHis72, αMet76, αPro77, αLys90, αCys104, αTyr140, βHis2, βTrp15, βTrp37, βMet55, βCys93, βCys112, βTyr130, βLys144, and βHis146. The antioxidant potential of the Hb molecule in the intracellular space and in the blood plasma is discussed.
Identifiants
pubmed: 31367820
doi: 10.1134/S1607672919030116
pii: 10.1134/S1607672919030116
doi:
Substances chimiques
Hemoglobins
0
Hydrogen Peroxide
BBX060AN9V
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
197-200Références
Biogerontology. 2000;1(1):31-40
pubmed: 11707918
Free Radic Biol Med. 2003 Apr 1;34(7):830-9
pubmed: 12654471
J Biol Chem. 2004 Mar 19;279(12):11600-7
pubmed: 14699100
Free Radic Biol Med. 2004 May 15;36(10):1214-23
pubmed: 15110386
J Biol Chem. 2007 Feb 16;282(7):4894-907
pubmed: 17178725
J Proteome Res. 2010 Aug 6;9(8):4061-70
pubmed: 20568812
Rapid Commun Mass Spectrom. 2011 Jan 15;25(1):184-90
pubmed: 21154902
Biochim Biophys Acta. 2014 Feb;1840(2):901-5
pubmed: 23648414
Biochim Biophys Acta. 2014 Aug;1844(8):1335-43
pubmed: 24657586
Free Radic Res. 2018 Jan;52(1):14-38
pubmed: 29284315
Biochim Biophys Acta Proteins Proteom. 2018 Aug;1866(8):875-884
pubmed: 29738861