Human placental methylome in the interplay of adverse placental health, environmental exposure, and pregnancy outcome.
DNA Methylation
/ physiology
Environmental Exposure
/ adverse effects
Epigenesis, Genetic
/ physiology
Epigenome
/ physiology
Female
Hormones
/ metabolism
Humans
Maternal Exposure
/ adverse effects
Maternal-Fetal Exchange
/ genetics
Placenta
/ cytology
Placentation
/ genetics
Pregnancy
Pregnancy Outcome
Single-Cell Analysis
Journal
PLoS genetics
ISSN: 1553-7404
Titre abrégé: PLoS Genet
Pays: United States
ID NLM: 101239074
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
entrez:
2
8
2019
pubmed:
2
8
2019
medline:
8
1
2020
Statut:
epublish
Résumé
The placenta is the interface between maternal and fetal circulations, integrating maternal and fetal signals to selectively regulate nutrient, gas, and waste exchange, as well as secrete hormones. In turn, the placenta helps create the in utero environment and control fetal growth and development. The unique epigenetic profile of the human placenta likely reflects its early developmental separation from the fetus proper and its role in mediating maternal-fetal exchange that leaves it open to a range of exogenous exposures in the maternal circulation. In this review, we cover recent advances in DNA methylation in the context of placental function and development, as well as the interaction between the pregnancy and the environment.
Identifiants
pubmed: 31369552
doi: 10.1371/journal.pgen.1008236
pii: PGENETICS-D-18-01973
pmc: PMC6675049
doi:
Substances chimiques
Hormones
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1008236Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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