Endothelium-Dependent Hyperpolarization (EDH) in Diabetes: Mechanistic Insights and Therapeutic Implications.
Animals
Biological Factors
/ genetics
Cardiovascular Diseases
/ drug therapy
Diabetes Mellitus, Type 1
/ complications
Diabetes Mellitus, Type 2
/ complications
Endothelium, Vascular
/ drug effects
Gap Junctions
/ drug effects
Gene Expression Regulation
Humans
Hypoglycemic Agents
/ therapeutic use
Insulin Resistance
Membrane Potentials
/ drug effects
Myocytes, Smooth Muscle
/ drug effects
Potassium Channels, Calcium-Activated
/ genetics
Risk Factors
Signal Transduction
Vasodilation
/ drug effects
Ca2+-activated K+ channel
antidiabetic agent
diabetes mellitus
endothelial function
endothelium-dependent hyperpolarization
endothelium-derived hyperpolarizing factor
gap junction
reactive oxygen species
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
31 Jul 2019
31 Jul 2019
Historique:
received:
03
07
2019
revised:
25
07
2019
accepted:
30
07
2019
entrez:
3
8
2019
pubmed:
3
8
2019
medline:
1
1
2020
Statut:
epublish
Résumé
Diabetes mellitus is one of the major risk factors for cardiovascular disease and is an important health issue worldwide. Long-term diabetes causes endothelial dysfunction, which in turn leads to diabetic vascular complications. Endothelium-derived nitric oxide is a major vasodilator in large-size vessels, and the hyperpolarization of vascular smooth muscle cells mediated by the endothelium plays a central role in agonist-mediated and flow-mediated vasodilation in resistance-size vessels. Although the mechanisms underlying diabetic vascular complications are multifactorial and complex, impairment of endothelium-dependent hyperpolarization (EDH) of vascular smooth muscle cells would contribute at least partly to the initiation and progression of microvascular complications of diabetes. In this review, we present the current knowledge about the pathophysiology and underlying mechanisms of impaired EDH in diabetes in animals and humans. We also discuss potential therapeutic approaches aimed at the prevention and restoration of EDH in diabetes.
Identifiants
pubmed: 31370156
pii: ijms20153737
doi: 10.3390/ijms20153737
pmc: PMC6695796
pii:
doi:
Substances chimiques
Biological Factors
0
Hypoglycemic Agents
0
Potassium Channels, Calcium-Activated
0
endothelium-dependent hyperpolarization factor
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Diabetologia. 1999 Feb;42(2):204-13
pubmed: 10064101
Circulation. 1999 Apr 13;99(14):1878-84
pubmed: 10199886
J Cardiovasc Pharmacol. 1999 Sep;34(3):461-7
pubmed: 10471008
Br J Pharmacol. 1999 Oct;128(3):837-43
pubmed: 10516670
Circ Res. 2000 Feb 18;86(3):341-6
pubmed: 10679487
J Cardiovasc Pharmacol. 2000 Apr;35(4):606-13
pubmed: 10774792
Br J Pharmacol. 2000 Jun;130(3):549-56
pubmed: 10821782
Diabetes. 2000 Feb;49(2):293-7
pubmed: 10868946
Hypertension. 2000 Oct;36(4):575-80
pubmed: 11040238
Diabetologia. 2000 Sep;43(9):1116-25
pubmed: 11043857
Eur J Pharmacol. 2001 Jan 5;411(1-2):155-160
pubmed: 11137870
Brain Res. 2001 Mar 2;893(1-2):195-201
pubmed: 11223007
Diabetes Care. 2001 Mar;24(3):533-8
pubmed: 11289481
Hypertension. 2001 May;37(5):1298-302
pubmed: 11358944
Am J Physiol Heart Circ Physiol. 2001 Jul;281(1):H232-40
pubmed: 11406490
Free Radic Biol Med. 2001 Jul 1;31(1):125-35
pubmed: 11425498
Invest Ophthalmol Vis Sci. 2001 Jul;42(8):1915-20
pubmed: 11431461
Hypertension. 2002 Jan;39(1):35-40
pubmed: 11799075
J Hypertens. 2002 Mar;20(3):439-46
pubmed: 11875311
Diabetes Metab Res Rev. 2002 Jan-Feb;18(1):49-56
pubmed: 11921418
Atherosclerosis. 2002 May;162(1):85-92
pubmed: 11947901
Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6392-7
pubmed: 11972050
Diabetes. 2002 May;51(5):1565-71
pubmed: 11978657
Life Sci. 2002 Sep 6;71(16):1863-77
pubmed: 12175702
Clin Sci (Lond). 2002 Sep;103(3):311-21
pubmed: 12193157
J Cell Physiol. 2002 Oct;193(1):80-92
pubmed: 12209883
J Pharmacol Exp Ther. 2003 Mar;304(3):1236-42
pubmed: 12604701
Br J Pharmacol. 2003 Apr;138(7):1285-94
pubmed: 12711629
Shock. 2003 Jun;19(6):508-12
pubmed: 12785004
Diabetes Res Clin Pract. 2003 Jul;61 Suppl 1:S35-9
pubmed: 12880693
Biochem Biophys Res Commun. 2003 Dec 26;312(4):1202-8
pubmed: 14652001
Cardiovasc Res. 2003 Dec 1;60(3):635-42
pubmed: 14659809
J Biol Chem. 2004 Jun 25;279(26):27219-24
pubmed: 15123628
Am J Physiol Heart Circ Physiol. 2004 Sep;287(3):H1064-71
pubmed: 15130892
Diabetologia. 2004 Jun;47(6):1038-46
pubmed: 15184978
Clin Exp Pharmacol Physiol. 2004 May-Jun;31(5-6):354-9
pubmed: 15191411
J Diabetes Complications. 2004 Nov-Dec;18(6):356-62
pubmed: 15531186
J Physiol. 2004 Nov 15;561(Pt 1):215-31
pubmed: 15550469
Diabetologia. 2004 Dec;47(12):2093-104
pubmed: 15662551
Arterioscler Thromb Vasc Biol. 2005 Apr;25(4):671-8
pubmed: 15705931
J Cardiovasc Pharmacol. 2005 May;45(5):485-90
pubmed: 15821445
Life Sci. 2005 Nov 19;78(1):14-21
pubmed: 16125203
Naunyn Schmiedebergs Arch Pharmacol. 2005 Jul;372(1):24-30
pubmed: 16133490
Br J Pharmacol. 2005 Dec;146(8):1110-8
pubmed: 16231005
Life Sci. 2006 May 30;79(1):63-71
pubmed: 16455110
J Hypertens. 2006 Feb;24(2):331-8
pubmed: 16508581
J Pharmacol Exp Ther. 2006 Jul;318(1):276-81
pubmed: 16565165
Vascul Pharmacol. 2006 Jun;44(6):450-60
pubmed: 16624628
Eur J Pharmacol. 2006 May 24;538(1-3):132-40
pubmed: 16678154
Br J Pharmacol. 2006 Jun;148(4):434-41
pubmed: 16682967
Planta Med. 2006 May;72(6):494-500
pubmed: 16773532
Vascul Pharmacol. 2007 Mar;46(3):153-9
pubmed: 17079193
J Hypertens. 2007 Feb;25(2):345-59
pubmed: 17211241
Diabetes. 2007 Feb;56(2):355-62
pubmed: 17259379
Brain Res. 2007 Mar 30;1139:29-33
pubmed: 17270155
Eur J Pharmacol. 2007 Apr 30;561(1-3):63-71
pubmed: 17291486
Br J Pharmacol. 2008 Feb;153(3):480-7
pubmed: 18037911
Hypertens Pregnancy. 2008;27(1):29-38
pubmed: 18293202
Diabetologia. 2008 May;51(5):872-81
pubmed: 18324386
Br J Pharmacol. 2008 Jun;154(3):652-62
pubmed: 18414396
Am J Physiol Cell Physiol. 2008 Jul;295(1):C221-30
pubmed: 18463230
Life Sci. 2008 Jul 18;83(3-4):110-7
pubmed: 18558413
Am J Physiol Regul Integr Comp Physiol. 2008 Sep;295(3):R829-39
pubmed: 18635451
Am J Physiol Heart Circ Physiol. 2008 Sep;295(3):H1165-H1176
pubmed: 18641273
Fundam Clin Pharmacol. 2008 Aug;22(4):363-77
pubmed: 18705747
Am J Physiol Heart Circ Physiol. 2008 Nov;295(5):H1982-8
pubmed: 18790831
Atherosclerosis. 2009 Jul;205(1):87-95
pubmed: 19111834
Clin Exp Pharmacol Physiol. 2009 Jul;36(7):729-33
pubmed: 19207721
J Pharmacol Exp Ther. 2009 Aug;330(2):413-22
pubmed: 19411610
PLoS One. 2009;4(5):e5557
pubmed: 19440378
Br J Pharmacol. 2009 Sep;158(2):621-32
pubmed: 19645710
Br J Pharmacol. 2010 Jan;159(1):154-65
pubmed: 20015296
Circ J. 2010 Apr;74(4):798-806
pubmed: 20154404
J Pharmacol Sci. 2010;112(3):299-309
pubmed: 20168046
Asian J Androl. 2010 Jul;12(4):599-604
pubmed: 20364152
Diabetes Obes Metab. 2010 Aug;12(8):689-99
pubmed: 20590746
J Pharmacol Exp Ther. 2010 Nov;335(2):284-93
pubmed: 20671071
Br J Pharmacol. 2011 Jan;162(2):365-77
pubmed: 20840539
Eur J Pharmacol. 2011 Mar 1;654(1):68-74
pubmed: 21187082
PLoS One. 2011 Jan 21;6(1):e16423
pubmed: 21283658
Vascul Pharmacol. 2011 Jul-Sep;55(1-3):2-9
pubmed: 21397040
J Physiol. 2011 Jul 1;589(Pt 13):3289-307
pubmed: 21576274
PLoS One. 2011;6(6):e20813
pubmed: 21673968
Microvasc Res. 2011 Nov;82(3):356-63
pubmed: 21983453
Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):370-7
pubmed: 22075246
J Sex Med. 2012 Jul;9(7):1789-800
pubmed: 22548917
Clin Exp Hypertens. 2013;35(2):112-9
pubmed: 22783963
Circ Res. 2012 Oct 12;111(9):1166-75
pubmed: 22896585
Free Radic Biol Med. 2013 Apr;57:10-21
pubmed: 23261940
Diabetes Res Clin Pract. 2013 Jun;100(3):330-9
pubmed: 23369225
Am J Physiol Heart Circ Physiol. 2013 Apr 1;304(7):H935-45
pubmed: 23376827
Arterioscler Thromb Vasc Biol. 2013 Apr;33(4):777-84
pubmed: 23413427
Front Physiol. 2013 Mar 11;4:38
pubmed: 23483845
Hypertension. 2013 Jul;62(1):134-9
pubmed: 23648706
Korean J Physiol Pharmacol. 2013 Jun;17(3):181-7
pubmed: 23776393
Pflugers Arch. 2014 Feb;466(2):307-17
pubmed: 23873353
Diabetes. 2014 Apr;63(4):1381-93
pubmed: 24353182
PLoS One. 2014 Jan 24;9(1):e86744
pubmed: 24475175
Life Sci. 2014 Apr 25;102(1):1-9
pubmed: 24583313
J Mol Cell Cardiol. 2014 Jul;72:364-73
pubmed: 24787473
Int J Cardiol. 2014 Jun 15;174(2):230-42
pubmed: 24794552
J Cardiovasc Pharmacol. 2014 Sep;64(3):277-84
pubmed: 24887687
Microcirculation. 2014 Nov;21(8):747-53
pubmed: 25047389
Mol Pharmacol. 2014 Nov;86(5):580-91
pubmed: 25123289
Am J Physiol Heart Circ Physiol. 2014 Oct 15;307(8):H1093-102
pubmed: 25128173
Diabetes Care. 2014 Oct;37(10):2884-94
pubmed: 25249673
PLoS One. 2014 Oct 10;9(10):e109432
pubmed: 25302606
J Med Chem. 2015 Mar 12;58(5):2047-67
pubmed: 25375908
J Biol Chem. 2015 Mar 13;290(11):7016-26
pubmed: 25605734
J Adv Res. 2013 Jul;4(4):375-83
pubmed: 25685443
Pharmacol Res. 2015 Apr;94:26-33
pubmed: 25697548
Am J Physiol Heart Circ Physiol. 2015 May 1;308(9):H1020-9
pubmed: 25724490
Biomolecules. 2015 Mar 16;5(1):194-222
pubmed: 25786107
Physiol Rev. 2015 Apr;95(2):645-90
pubmed: 25834234
Eur J Pharmacol. 2015 Sep 15;763(Pt A):3-14
pubmed: 25987425
PLoS One. 2015 Jun 05;10(6):e0128359
pubmed: 26047504
Am J Physiol Heart Circ Physiol. 2015 Aug 15;309(4):H592-604
pubmed: 26092991
Eur J Cell Biol. 2015 Jul-Sep;94(7-9):391-400
pubmed: 26116074
Atherosclerosis. 2015 Sep;242(1):191-8
pubmed: 26204495
Am J Physiol Cell Physiol. 2015 Nov 1;309(9):C593-9
pubmed: 26269457
Biomolecules. 2015 Aug 17;5(3):1870-911
pubmed: 26287261
J Am Heart Assoc. 2015 Aug 24;4(8):e002062
pubmed: 26304940
Eur J Pharmacol. 2015 Nov 15;767:17-23
pubmed: 26420355
Int J Mol Sci. 2015 Oct 23;16(10):25234-63
pubmed: 26512646
Microcirculation. 2016 Jan;23(1):15-32
pubmed: 26541094
PLoS One. 2015 Nov 30;10(11):e0143941
pubmed: 26618855
Trends Cell Biol. 2016 Mar;26(3):177-189
pubmed: 26653791
J Cardiovasc Pharmacol. 2016 May;67(5):373-87
pubmed: 26657714
Acta Physiol (Oxf). 2017 Jan;219(1):138-151
pubmed: 26680745
Acta Physiol (Oxf). 2017 Jan;219(1):22-96
pubmed: 26706498
Acta Physiol (Oxf). 2017 Jan;219(1):152-161
pubmed: 26752699
Nitric Oxide. 2016 Feb 29;53:35-44
pubmed: 26768833
J Diabetes Complications. 2016 May-Jun;30(4):738-45
pubmed: 26781070
J Physiol. 2016 Jun 15;594(12):3271-85
pubmed: 26840527
Basic Res Cardiol. 2016 Mar;111(2):21
pubmed: 26907473
Vascul Pharmacol. 2016 Nov;86:31-40
pubmed: 26975734
Cardiovasc Diabetol. 2016 Mar 18;15:46
pubmed: 26993793
Lancet. 2016 Apr 9;387(10027):1513-1530
pubmed: 27061677
Prostaglandins Other Lipid Mediat. 2016 Sep;125:80-9
pubmed: 27184755
Diabetes. 2016 Aug;65(8):2249-57
pubmed: 27207517
BMC Cell Biol. 2016 May 24;17 Suppl 1:11
pubmed: 27229925
Diabetes. 2016 Sep;65(9):2742-53
pubmed: 27246914
Free Radic Biol Med. 2016 Aug;97:274-284
pubmed: 27320188
J Cereb Blood Flow Metab. 2017 Jun;37(6):2171-2184
pubmed: 27466375
J Diabetes Res. 2016;2016:9051426
pubmed: 27595114
Acta Physiol (Oxf). 2017 Jan;219(1):324-334
pubmed: 27639255
Acta Physiol (Oxf). 2017 May;220(1):150-166
pubmed: 27683007
Hypertension. 2017 Jan;69(1):143-153
pubmed: 27872234
Int J Nephrol Renovasc Dis. 2016 Nov 14;9:279-290
pubmed: 27881924
Biochem J. 2016 Dec 15;473(24):4527-4550
pubmed: 27941030
Free Radic Biol Med. 2017 Aug;109:4-10
pubmed: 27988339
Molecules. 2016 Dec 31;22(1):null
pubmed: 28042862
Circ Res. 2017 Jan 6;120(1):229-243
pubmed: 28057795
Free Radic Biol Med. 2017 May;106:168-183
pubmed: 28212823
Pharmacol Ther. 2017 Jun;174:79-96
pubmed: 28223224
Sci Rep. 2017 Mar 13;7:44322
pubmed: 28287157
Curr Med Chem. 2017;24(28):3104-3114
pubmed: 28403787
Diab Vasc Dis Res. 2017 Jul;14(4):353-362
pubmed: 28429615
Br J Pharmacol. 2018 Apr;175(8):1279-1292
pubmed: 28430357
Eur J Pharmacol. 2017 Jul 15;807:151-158
pubmed: 28433656
Diabetes. 2017 Oct;66(10):2681-2690
pubmed: 28465407
Redox Biol. 2017 Oct;13:370-385
pubmed: 28667906
Eur J Clin Invest. 2017 Aug;47(8):600-611
pubmed: 28722106
PLoS One. 2017 Aug 17;12(8):e0183124
pubmed: 28817716
Sci Rep. 2017 Sep 8;7(1):10975
pubmed: 28887562
Diseases. 2016 Jul 11;4(3):null
pubmed: 28933404
J Am Heart Assoc. 2017 Oct 17;6(10):null
pubmed: 29042424
Int J Cardiol. 2018 Feb 1;252:44-51
pubmed: 29191384
Physiol Rep. 2017 Dec;5(23):
pubmed: 29212858
Mol Cell Biochem. 2018 Aug;445(1-2):187-194
pubmed: 29305679
Biochem Pharmacol. 2018 Mar;149:60-76
pubmed: 29307653
Vascul Pharmacol. 2018 Apr;103-105:29-35
pubmed: 29339138
Eur J Pharmacol. 2018 Mar 5;822:59-68
pubmed: 29355555
Int J Mol Sci. 2018 Jan 21;19(1):null
pubmed: 29361737
Int J Mol Med. 2018 Apr;41(4):1867-1876
pubmed: 29393353
Diabetes Metab Res Rev. 2018 Jul;34(5):e2995
pubmed: 29471582
J Am Heart Assoc. 2018 Mar 3;7(5):
pubmed: 29502106
Redox Biol. 2018 Jun;16:215-225
pubmed: 29524844
Int J Mol Sci. 2018 Mar 21;19(4):null
pubmed: 29561829
Microcirculation. 2018 Jul;25(5):e12456
pubmed: 29665152
Acta Physiol (Oxf). 2019 Jan;225(1):e13108
pubmed: 29858558
Int J Mol Sci. 2018 Jun 05;19(6):null
pubmed: 29874791
Arterioscler Thromb Vasc Biol. 2018 Jul;38(7):1427-1439
pubmed: 29880486
Basic Clin Pharmacol Toxicol. 2018 Nov;123(5):523-538
pubmed: 29890033
Diabetologia. 2018 Oct;61(10):2108-2117
pubmed: 30132036
Peptides. 2019 Jan;111:26-32
pubmed: 30227157
J Physiol. 2019 Mar;597(5):1321-1335
pubmed: 30506579
Physiol Res. 2019 Apr 30;68(2):219-231
pubmed: 30628831
Adv Exp Med Biol. 2019;1115:77-95
pubmed: 30649756
Eur J Pharmacol. 2019 Jun 15;853:33-40
pubmed: 30876977
Wiley Interdiscip Rev Syst Biol Med. 2019 Sep;11(5):e1448
pubmed: 30884210
Cardiovasc Diabetol. 2019 Mar 18;18(1):35
pubmed: 30885203
Front Physiol. 2019 Mar 04;10:186
pubmed: 30886586
Int J Mol Sci. 2019 Mar 19;20(6):null
pubmed: 30893836
Circ Res. 2019 May 10;124(10):1473-1481
pubmed: 30900949
J Pharmacol Exp Ther. 2019 Jun;369(3):375-388
pubmed: 30910920
Curr Opin Pharmacol. 2019 Apr;45:8-15
pubmed: 30986569
J Transl Med. 2019 Apr 16;17(1):127
pubmed: 30992077
Curr Opin Pharmacol. 2019 Apr;45:33-41
pubmed: 31031224
Arterioscler Thromb Vasc Biol. 2019 Jun;39(6):1072-1087
pubmed: 31043073
Cytokine. 2019 Aug;120:99-106
pubmed: 31054482
Physiol Rep. 2019 May;7(9):e14095
pubmed: 31087517
Br J Pharmacol. 2019 Aug;176(16):2905-2921
pubmed: 31116877
Mol Cell Biochem. 2019 Sep;459(1-2):121-130
pubmed: 31127491
Curr Opin Pharmacol. 2019 Apr;45:81-86
pubmed: 31170683
Nature. 1981 Jul 2;292(5818):17-21
pubmed: 6168915
Biochem Biophys Res Commun. 1995 Mar 17;208(2):492-7
pubmed: 7695598
Diabetes. 1993 Oct;42(10):1497-505
pubmed: 8375590
Circulation. 1995 Dec 15;92(12):3520-6
pubmed: 8521575
Br J Pharmacol. 1995 Sep;116(1):1541-3
pubmed: 8564216
J Clin Invest. 1997 Mar 1;99(5):1016-27
pubmed: 9062360
Br J Pharmacol. 1997 Apr;120(7):1207-14
pubmed: 9105694
Cardiovasc Res. 1997 Apr;34(1):169-78
pubmed: 9217887
J Membr Biol. 1997 Jul 15;158(2):147-58
pubmed: 9230092
Br J Pharmacol. 1997 Aug;121(7):1383-91
pubmed: 9257918
Circ Res. 1997 Dec;81(6):996-1004
pubmed: 9400380
Diabetes. 1998 Jan;47(1):104-12
pubmed: 9421382
Circ Res. 1998 Apr 6;82(6):677-85
pubmed: 9546376
Diabetes. 1998 Jun;47(6):931-6
pubmed: 9604871
Br J Pharmacol. 1998 Apr;123(8):1509-16
pubmed: 9605555