Medroxyprogesterone acetate concentrations among HIV-infected depot-medroxyprogesterone acetate users receiving antiretroviral therapy in Lilongwe, Malawi.
Africa
Antiretroviral therapy
Depot medroxyprogesterone acetate
HIV
Journal
Contraception
ISSN: 1879-0518
Titre abrégé: Contraception
Pays: United States
ID NLM: 0234361
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
03
04
2019
revised:
04
07
2019
accepted:
24
07
2019
pubmed:
3
8
2019
medline:
2
10
2020
entrez:
3
8
2019
Statut:
ppublish
Résumé
To compare medroxyprogesterone acetate (MPA) concentrations between HIV-positive women on antiretroviral therapy (ART) and HIV-negative women initiating depot medroxyprogesterone (DMPA) injectable. Secondary analysis of 28 HIV-positive women on non-nucleoside reverse transcriptase inhibitor-containing ART regimens and 10 HIV-negative women randomized to initiate DMPA in a clinical trial of progestin contraception in Malawi. MPA concentrations were significantly lower among HIV-positive women on ART, compared with HIV-negative women, at week 4 and week 13 (p=.03 for both), but not at day 3 or week 26 post-DMPA initiation. Antiretroviral medications may affect MPA metabolism in HIV-positive African women.
Identifiants
pubmed: 31374188
pii: S0010-7824(19)30372-5
doi: 10.1016/j.contraception.2019.07.144
pmc: PMC7245365
mid: NIHMS1586152
pii:
doi:
Substances chimiques
Anti-HIV Agents
0
Contraceptive Agents, Female
0
Delayed-Action Preparations
0
Progestins
0
Medroxyprogesterone Acetate
C2QI4IOI2G
Banques de données
ClinicalTrials.gov
['NCT02103660']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
402-405Subventions
Organisme : FIC NIH HHS
ID : K01 TW009657
Pays : United States
Organisme : OSELS CDC HHS
ID : U36 OE000002
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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