Do dehydroepiandrosterone, progesterone, and testosterone influence women's depression and anxiety levels? Evidence from hair-based hormonal measures of 2105 rural Indian women.
Adult
Aged
Aged, 80 and over
Androgens
/ analysis
Anxiety
/ metabolism
Anxiety Disorders
/ metabolism
Cohort Studies
Dehydroepiandrosterone
/ analysis
Dehydroepiandrosterone Sulfate
/ analysis
Depression
/ epidemiology
Depressive Disorder
/ metabolism
Estradiol
/ analysis
Female
Gonadal Steroid Hormones
/ analysis
Hair
/ chemistry
Humans
Middle Aged
Progesterone
/ analysis
Rural Population
Sex Hormone-Binding Globulin
/ analysis
Testosterone
/ analysis
Women's Health
Androgens
Anxiety
Depression
India
Sex hormones
Women
Journal
Psychoneuroendocrinology
ISSN: 1873-3360
Titre abrégé: Psychoneuroendocrinology
Pays: England
ID NLM: 7612148
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
12
01
2019
revised:
16
06
2019
accepted:
16
07
2019
pubmed:
3
8
2019
medline:
24
6
2020
entrez:
3
8
2019
Statut:
ppublish
Résumé
Depressive and anxiety disorders substantially contribute to the global burden of disease, particularly in poor countries. Higher prevalence rates for both disorders among women indicate sex hormones may be integrated in the pathophysiology of these disorders. The Kshetriya Gramin Financial Services study surveyed a random sample of 4160 households across 876 villages in rural Tamil Nadu, India. An interviewer-administered questionnaire was conducted to quantify depressive (K6-D) and anxiety (K6-A) symptoms. Alongside, hair samples for sex hormone profiling were collected from a subsample of 2105 women aged 18-85 years. Importantly, 5.9%, 14.8%, and 46.3% of samples contained non-detectable hormone levels for dehydroepiandrosterone, progesterone, and testosterone, respectively. Our primary analysis imputes values for the non-detectable sample and we check robustness of results when non-detectable values are dropped. In this cohort of women from rural India, higher depressive symptomatology is associated with lower levels of dehydroepiandrosterone and higher depressive and anxiety symptoms are associated with higher levels of testosterone. Progesterone shows no clear association with either depressive or anxiety symptoms. These results support a potential protective effect of higher endogenous dehydroepiandrosterone levels. An important caveat on the potential negative effect of hair testosterone levels on women's mental health is that the testosterone analysis is sensitive to how non-detectable values are treated.
Identifiants
pubmed: 31374371
pii: S0306-4530(19)30031-9
doi: 10.1016/j.psyneuen.2019.104382
pmc: PMC6842697
mid: NIHMS1536149
pii:
doi:
Substances chimiques
Androgens
0
Gonadal Steroid Hormones
0
Sex Hormone-Binding Globulin
0
Testosterone
3XMK78S47O
Dehydroepiandrosterone
459AG36T1B
Progesterone
4G7DS2Q64Y
Estradiol
4TI98Z838E
Dehydroepiandrosterone Sulfate
57B09Q7FJR
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
104382Subventions
Organisme : NICHD NIH HHS
ID : R01 HD069546
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.
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