Spatial and functional heterogeneity of follicular helper T cells in autoimmunity.
Journal
Current opinion in immunology
ISSN: 1879-0372
Titre abrégé: Curr Opin Immunol
Pays: England
ID NLM: 8900118
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
03
06
2019
revised:
21
06
2019
accepted:
25
06
2019
pubmed:
3
8
2019
medline:
31
7
2020
entrez:
3
8
2019
Statut:
ppublish
Résumé
Follicular helper T cells provide signals that promote B cell development, proliferation, and production of affinity matured and appropriately isotype switched antibodies. In addition to their classical locations within B cell follicles and germinal centers therein, B cell helper T cells are also found in extrafollicular spaces - either in secondary lymphoid or non-lymphoid tissues. Both follicular and extrafollicular T helper cells drive autoantibody-mediated autoimmunity. Interfering with B cell help provided by T cells can ameliorate autoimmune disease in animal models and human patients. The next frontier in Tfh cell biology will be identification of Tfh cell-specific pathogenic changes in autoimmunity and exploiting them for therapeutic purposes.
Identifiants
pubmed: 31374450
pii: S0952-7915(19)30015-9
doi: 10.1016/j.coi.2019.06.005
pmc: PMC7255639
mid: NIHMS1563161
pii:
doi:
Substances chimiques
Autoantibodies
0
Biomarkers
0
Cytokines
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-9Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR074545
Pays : United States
Organisme : NIAMS NIH HHS
ID : R37 AR040072
Pays : United States
Informations de copyright
Copyright © 2019. Published by Elsevier Ltd.
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