Molecular codes and in vitro generation of hypocretin and melanin concentrating hormone neurons.
Animals
Hypothalamic Hormones
/ genetics
Hypothalamus
/ cytology
Induced Pluripotent Stem Cells
/ cytology
Intercellular Signaling Peptides and Proteins
/ genetics
Melanins
/ genetics
Mice
Mice, Transgenic
Nerve Tissue Proteins
/ genetics
Neurons
/ cytology
Orexins
/ genetics
Pituitary Hormones
/ genetics
HCRT/OREXIN
MCH
Peg3
iPSC
transcription factor
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
20 08 2019
20 08 2019
Historique:
pubmed:
4
8
2019
medline:
24
3
2020
entrez:
4
8
2019
Statut:
ppublish
Résumé
Hypocretin/orexin (HCRT) and melanin concentrating hormone (MCH) neuropeptides are exclusively produced by the lateral hypothalamus and play important roles in sleep, metabolism, reward, and motivation. Loss of HCRT (ligands or receptors) causes the sleep disorder narcolepsy with cataplexy in humans and in animal models. How these neuropeptides are produced and involved in diverse functions remain unknown. Here, we developed methods to sort and purify HCRT and MCH neurons from the mouse late embryonic hypothalamus. RNA sequencing revealed key factors of fate determination for HCRT (
Identifiants
pubmed: 31375626
pii: 1902148116
doi: 10.1073/pnas.1902148116
pmc: PMC6708384
doi:
Substances chimiques
Hcrt protein, mouse
0
Hypothalamic Hormones
0
Intercellular Signaling Peptides and Proteins
0
Melanins
0
Nerve Tissue Proteins
0
Orexins
0
Pituitary Hormones
0
QRFP peptide
0
melanin-concentrating hormone
67382-96-1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
17061-17070Informations de copyright
Copyright © 2019 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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