Random peptide mixtures entrapped within a copper-cuprite matrix: new antimicrobial agent against methicillin-resistant Staphylococcus aureus.

Anti-Infective Agents / isolation & purification Copper / chemistry Drug Resistance, Microbial / drug effects Methicillin-Resistant Staphylococcus aureus / drug effects Peptides / isolation & purification

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
02 08 2019
Historique:
received: 19 03 2019
accepted: 10 07 2019
entrez: 4 8 2019
pubmed: 4 8 2019
medline: 20 11 2020
Statut: epublish

Résumé

The emergence of global antibiotic resistance necessitates the urgent need to develop new and effective antimicrobial agents. Combination of two antimicrobial agents can potentially improve antimicrobial potency and mitigate the development of resistance. Therefore, we have utilized metal molecular doping methodology whereby antimicrobial random peptides mixture (RPMs) are entrapped in a bactericidal copper metal matrix. The copper/RPM composite exhibits greater antimicrobial activity toward methicillin-resistant Staphylococcus aureus (MRSA) than either copper or RPMs alone. Our findings indicate that this bactericidal antimicrobial biomaterial could be utilized to efficiently eradicate antibiotic-resistant pathogenic bacteria for health, agricultural and environmental applications.

Identifiants

DOI: 10.1038/s41598-019-47315-0 PMID: 31375700 PMC: PMC6677760
pubmed: 31375700
doi: 10.1038/s41598-019-47315-0
pii: 10.1038/s41598-019-47315-0
pmc: PMC6677760
doi:

Substances chimiques

Anti-Infective Agents 0
Peptides 0
Copper 789U1901C5

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

11215

Références

J Mater Chem B. 2016 Jun 28;4(24):4322-4329
pubmed: 32263414
J Inorg Biochem. 2017 Dec;177:159-170
pubmed: 28964993
Angew Chem Int Ed Engl. 2017 Jul 3;56(28):8099-8103
pubmed: 28557193
Peptides. 2010 Nov;31(11):1995-2002
pubmed: 20713108
J Antibiot (Tokyo). 2017 May;70(5):520-526
pubmed: 28246379
Acc Chem Res. 2014 Feb 18;47(2):579-92
pubmed: 24283194
Appl Microbiol Biotechnol. 2014 Feb;98(3):1001-9
pubmed: 24305741
J Hosp Infect. 2012 Aug;81(4):217-23
pubmed: 22738611
Biochemistry. 2017 Aug 15;56(32):4244-4255
pubmed: 28763199
Phytopathology. 2014 Feb;104(2):134-42
pubmed: 23901828
Pediatrics. 1948 Sep;2(3):272-89
pubmed: 18880098
Chem Commun (Camb). 2016 Jun 4;52(44):7102-5
pubmed: 27161246
Sci Rep. 2017 Mar 15;7:44554
pubmed: 28294164
Plant Dis. 1998 Apr;82(4):397-406
pubmed: 30856888
Sci Rep. 2017 Jun 23;7(1):4161
pubmed: 28646180
Nat Rev Microbiol. 2013 Jun;11(6):371-84
pubmed: 23669886
J Biomed Mater Res. 2000 Dec 15;52(4):662-8
pubmed: 11033548
Metallomics. 2015 Jun;7(6):957-64
pubmed: 25652326
Am J Clin Nutr. 1996 May;63(5):791S-6S
pubmed: 8615366
Curr Opin Microbiol. 2011 Oct;14(5):519-23
pubmed: 21900036
Nat Rev Microbiol. 2005 Mar;3(3):238-50
pubmed: 15703760
Mol Biol Evol. 2015 May;32(5):1175-85
pubmed: 25618457
J Bacteriol. 1969 May;98(2):447-52
pubmed: 5784204
Mol Ecol. 2017 Oct;26(19):5334-5343
pubmed: 28762573
J Membr Biol. 2011 Jan;239(1-2):27-34
pubmed: 21225255
ChemMedChem. 2014 Aug;9(8):1892-901
pubmed: 24803240
Biomaterials. 2009 Mar;30(7):1263-7
pubmed: 19091400
Phytomedicine. 2013 Jun 15;20(8-9):714-8
pubmed: 23537748
J Am Chem Soc. 2013 Aug 14;135(32):11748-51
pubmed: 23909610

Auteurs

Tal Stern Bauer (TS)

Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot, 76100, Israel.
The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel.

Barak Menagen (B)

Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel.
The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel.

David Avnir (D)

Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel.
The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel.

Zvi Hayouka (Z)

Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot, 76100, Israel. zvi.hayouka@mail.huji.ac.il.
The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel. zvi.hayouka@mail.huji.ac.il.
ORCID: 0000-0003-3582-4029

Articles similaires

Proteomimetic polymer blocks mitochondrial damage, rescues Huntington's neurons, and slows onset of neuropathology in vivo.

Wonmin Choi, Mara Fattah, Yutong Shang et al.
1.00
Animals Huntington Disease Mitochondria Neurons Mice

Two codependent routes lead to high-level MRSA.

Abimbola Feyisara Adedeji-Olulana, Katarzyna Wacnik, Lucia Lafage et al.
1.00
Methicillin-Resistant Staphylococcus aureus Penicillin-Binding Proteins Peptidoglycan Bacterial Proteins Anti-Bacterial Agents

Bacteria divide to conquer antibiotics.

Ewan Harrison
1.00
Cell Division Anti-Bacterial Agents Methicillin-Resistant Staphylococcus aureus Methicillin Resistance

Aminoacid functionalised magnetite nanoparticles Fe

Spoială Angela, Motelica Ludmila, Ilie Cornelia-Ioana et al.
1.00
Magnetite Nanoparticles Tryptophan Biocompatible Materials Microbial Sensitivity Tests Humans

Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Random peptide mixtures entrapped within a...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Cuivre › Random peptide mixtures entrapped within a...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance microbienne aux médicaments › Random peptide mixtures entrapped within a...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Cocci à Gram positif › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › Staphylococcus aureus résistant à la méticilline › Random peptide mixtures entrapped within a...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Random peptide mixtures entrapped within a...