Mechanism of CuO nano-particles on stimulating production of actinorhodin in Streptomyces coelicolor by transcriptional analysis.

Anthraquinones / isolation & purification Anti-Bacterial Agents / biosynthesis Biosynthetic Pathways / drug effects Copper / pharmacology Gene Expression Profiling Gene Expression Regulation, Bacterial / drug effects Nanoparticles Reactive Oxygen Species / metabolism Streptomyces coelicolor / drug effects

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
02 08 2019
Historique:
received: 08 01 2019
accepted: 05 07 2019
entrez: 4 8 2019
pubmed: 4 8 2019
medline: 11 11 2020
Statut: epublish

Résumé

In this research, antibiotic-producing bacteria, Streptomyces coelicolor (S. coelicolor) M145, was exposed to copper oxide (CuO) particles to investigate the effects of nano-particles (NPs) on antibiotic production. Results showed that a higher yield of antibiotics was obtained with smaller particle sizes of CuO NPs. When exposed to 10 mg/L of 40 nm CuO NPs, the maximum amount of actinorhodin (ACT) obtained was 2.6 mg/L after 144 h, which was 2.0-fold greater than that of control. However, the process was inhibited when the concentration of CuO NPs was increased to higher than 20 mg/L. Transcriptome analysis showed that all the genes involved in the ACT cluster were significantly up-regulated after exposure to 10 mg/L NPs, which could be the direct cause of the increase of ACT production. Additionally, some genes related to the generation of acetyl-coA were up-regulated. In this way, CuO NPs led to an increase of secondary metabolites. The mechanism related to these changes indicated that nano-particle‒induced ROS and Cu

Identifiants

DOI: 10.1038/s41598-019-46833-1 PMID: 31375702 PMC: PMC6677739
pubmed: 31375702
doi: 10.1038/s41598-019-46833-1
pii: 10.1038/s41598-019-46833-1
pmc: PMC6677739
doi:

Substances chimiques

Anthraquinones 0
Anti-Bacterial Agents 0
Reactive Oxygen Species 0
Copper 789U1901C5
actinorhodin G4HH387T6Z
cupric oxide V1XJQ704R4

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

11253

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Auteurs

Xiaomei Liu (X)

Key Laboratory of Pollution Processes and Environmental Criteria (Ministry of Education), Tianjin Engineering Research Center of Environmental Diagnosis and Contamination Remediation, College of Environmental Science and Engineering, Nankai University, Tianjin, 300350, China.

Jingchun Tang (J)

Key Laboratory of Pollution Processes and Environmental Criteria (Ministry of Education), Tianjin Engineering Research Center of Environmental Diagnosis and Contamination Remediation, College of Environmental Science and Engineering, Nankai University, Tianjin, 300350, China. tangjch@nankai.edu.cn.

Lan Wang (L)

Key Laboratory of Pollution Processes and Environmental Criteria (Ministry of Education), Tianjin Engineering Research Center of Environmental Diagnosis and Contamination Remediation, College of Environmental Science and Engineering, Nankai University, Tianjin, 300350, China.

Rutao Liu (R)

School of Environmental Science and Engineering, Shandong University, China-America CRC for Environment & Health, 72# Jimo Binhai Road, Qingdao, Shandong, 266237, P.R. China.

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Classifications MeSH

questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Anthracènes › Anthraquinones › Mechanism of CuO nano-particles on stimulating...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Mechanism of CuO nano-particles on stimulating...
questionsmedicales.fr › Métabolisme › Voies et réseaux métaboliques › Voies de biosynthèse › Mechanism of CuO nano-particles on stimulating...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Cuivre › Mechanism of CuO nano-particles on stimulating...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › Mechanism of CuO nano-particles on stimulating...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes bactériens › Mechanism of CuO nano-particles on stimulating...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Mechanism of CuO nano-particles on stimulating...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Mechanism of CuO nano-particles on stimulating...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets sporulés à Gram positif › Streptomycetaceae › Streptomyces › Streptomyces coelicolor › Mechanism of CuO nano-particles on stimulating...