High dose folic acid during pregnancy and the risk of autism; The birth order bias: A nested case-control study.
Autism Spectrum Disorder
/ chemically induced
Case-Control Studies
Child
Databases, Factual
Dose-Response Relationship, Drug
Female
Folic Acid
/ administration & dosage
Humans
Israel
Logistic Models
Male
Maternal Exposure
/ adverse effects
Medical Records
Multivariate Analysis
Pregnancy
Prenatal Exposure Delayed Effects
/ chemically induced
Autistic spectrum disorder
Birth order
Folate
Folic acid
Pregnancy
Journal
Reproductive toxicology (Elmsford, N.Y.)
ISSN: 1873-1708
Titre abrégé: Reprod Toxicol
Pays: United States
ID NLM: 8803591
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
22
05
2019
revised:
23
07
2019
accepted:
30
07
2019
pubmed:
4
8
2019
medline:
12
5
2020
entrez:
4
8
2019
Statut:
ppublish
Résumé
To examine whether there is an association between the cumulative dose of folic acid (FA) purchased by mothers, and risk of autistic spectrum disorders (ASD) in their progeny. We identified 2009 singletons who received an ASD diagnosis from a cohort of 480,526 children born in a large health organization in Israel from 2000 through 2013. ASD patients were individually matched to ASD-free children (n = 19,886). Median cumulative daily doses of supplemented FA during the 12-month period prior to the end of pregnancy (from dispensing records) were compared using conditional logistic regression models. Children with ASD were more likely to be first-born, and birth-order was significantly associated with FA use. In multivariable analysis, there were no statistically significant differences in the cumulative dose of FA between the groups. Birth order effects need to be accounted for in analyses aiming to decipher the associations between gestational FA use and developmental outcomes.
Identifiants
pubmed: 31376478
pii: S0890-6238(19)30262-X
doi: 10.1016/j.reprotox.2019.07.083
pii:
doi:
Substances chimiques
Folic Acid
935E97BOY8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
173-177Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.