Cholestatic liver disease results increased production of reactive aldehydes and an atypical periportal hepatic antioxidant response.

Adult Aldehydes / metabolism Animals Antioxidants / metabolism Cholestasis / metabolism Female Glutathione Transferase / metabolism Humans Inflammation Liver / metabolism Liver Diseases / metabolism Lysosomes / metabolism Mice Mice, Inbred C57BL Mice, Knockout Middle Aged NF-kappa B / metabolism Oxidation-Reduction Oxidative Stress Proteomics Ribosomes / metabolism Signal Transduction Superoxide Dismutase / metabolism Up-Regulation
Cholestasis Inflammation Liver Oxidative stress Protein carbonylation Reactive aldehyde

Journal

Free radical biology & medicine
ISSN: 1873-4596
Titre abrégé: Free Radic Biol Med
Pays: United States
ID NLM: 8709159

Informations de publication

Date de publication:
01 11 2019
Historique:
received: 29 01 2019
revised: 30 06 2019
accepted: 31 07 2019
pubmed: 5 8 2019
medline: 8 8 2020
entrez: 5 8 2019
Statut: ppublish

Résumé

Cholangiopathies such as primary sclerosing cholangitis (PSC) are chronic liver diseases characterized by increased cholestasis, biliary inflammation and oxidative stress. The objective of this study was to elucidate the impact of cholestatic injury on oxidative stress-related factors. Using hepatic tissue and whole cell liver extracts (LE) isolated from 11-week old C57BL/6J (WT) and Mdr2

Identifiants

DOI: 10.1016/j.freeradbiomed.2019.07.036 PMID: 31377417 PMC: PMC6848778
pubmed: 31377417
pii: S0891-5849(19)30160-1
doi: 10.1016/j.freeradbiomed.2019.07.036
pmc: PMC6848778
mid: NIHMS1537221
pii:
doi:

Substances chimiques

Aldehydes 0
Antioxidants 0
NF-kappa B 0
Superoxide Dismutase EC 1.15.1.1
superoxide dismutase 2 EC 1.15.1.1
Glutathione Transferase EC 2.5.1.18

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

101-114

Subventions

Organisme : NIDDK NIH HHS
ID : P30 DK048520
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR025780
Pays : United States
Organisme : NIH HHS
ID : R21 OD026444
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA046934
Pays : United States
Organisme : NIAAA NIH HHS
ID : R37 AA009300
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK123738
Pays : United States
Organisme : BLRD VA
ID : I01 BX002182
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK007038
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK104713
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK103712
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA009300
Pays : United States
Organisme : NIDDK NIH HHS
ID : R56 DK123738
Pays : United States
Organisme : NIDDK NIH HHS
ID : R37 DK050189
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK095491
Pays : United States

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

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Auteurs

Colin T Shearn (CT)

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States. Electronic address: Colin.Shearn@ucdenver.edu.

Blair Fennimore (B)

Department of Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States.

David J Orlicky (DJ)

Department of Pathology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States.

Yue R Gao (YR)

Department of Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States.

Laura M Saba (LM)

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States.

Kayla D Battista (KD)

Department of Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States.

Stefanos Aivazidis (S)

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States.

Mohammed Assiri (M)

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States.

Peter S Harris (PS)

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States.

Cole Michel (C)

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States.

Gary F Merrill (GF)

Department of Biochemistry and Biophysics, Oregon State University, Corvalis, OR, 97331, United States.

Edward E Schmidt (EE)

Department of Microbiology and Immunology, Montana State University, Bozeman, MT, 59717, United States.

Sean P Colgan (SP)

Department of Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States.

Dennis R Petersen (DR)

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Cholestatic liver disease results increased...
questionsmedicales.fr › Composés chimiques organiques › Aldéhydes › Cholestatic liver disease results increased...
questionsmedicales.fr › Eucaryotes › Animaux › Cholestatic liver disease results increased...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › Cholestatic liver disease results increased...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladie des voies biliaires › Maladies des canaux biliaires › Cholestase › Cholestatic liver disease results increased...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Alkyl et aryl transferases › Glutathione transferase › Cholestatic liver disease results increased...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Cholestatic liver disease results increased...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Cholestatic liver disease results increased...
questionsmedicales.fr › Système digestif › Foie › Cholestatic liver disease results increased...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Cholestatic liver disease results increased...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Lysosomes › Cholestatic liver disease results increased...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Cholestatic liver disease results increased...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Cholestatic liver disease results increased...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Cholestatic liver disease results increased...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Cholestatic liver disease results increased...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteur de transcription NF-kappa B › Cholestatic liver disease results increased...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Cholestatic liver disease results increased...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Cholestatic liver disease results increased...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Protéomique › Cholestatic liver disease results increased...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Ribosomes › Cholestatic liver disease results increased...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Cholestatic liver disease results increased...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Superoxide dismutase › Cholestatic liver disease results increased...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Régulation positive › Cholestatic liver disease results increased...