Colin T Shearn

Affiliations

Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

Publications (17)

Multivalent lipid targeting by the calcium-independent C2A domain of synaptotagmin-like protein 4/granuphilin.

The Journal of biological chemistry

Avec: Aml A Alnaas , Abena Watson-Siriboe , Sherleen Tran , Mikias Negussie , Jack A Henderson , J Ryan Osterberg , Nara L Chon , Beckston M Harrott , Julianna Oviedo , Tatyana Lyakhova , Cole Michel , Nichole Reisdorph , Richard Reisdorph , Colin T Shearn , Hai Lin , Jefferson D Knight

Identification of Dose-Dependent DNA Damage and Repair Responses From Subchronic Exposure to 1,4-Dioxane in Mice Using a Systems Analysis Approach.

Toxicological sciences : an official journal of the Society of Toxicology

Avec: Georgia Charkoftaki , Jaya Prakash Golla , Alvaro Santos-Neto , David J Orlicky , Rolando Garcia-Milian , Ying Chen , Nicholas J W Rattray , Yuping Cai , Yewei Wang , Colin T Shearn , Varvara Mironova , Yensheng Wang , Caroline H Johnson , David C Thompson , Vasilis Vasiliou

Endocrine pancreas-specific

bioRxiv : the preprint server for biology

Avec: Emily A Davidson , Ying Chen , Surendra Singh , David J Orlicky , Brian Thompson , Yewei Wang , Georgia Charkoftaki , Tristan A Furnary , Rebecca L Cardone , Richard G Kibbey , Colin T Shearn , Daniel W Nebert , David C Thompson , Vasilis Vasiliou

Cholestatic liver disease results increased production of reactive aldehydes and an atypical periportal hepatic antioxidant response.

Free radical biology & medicine

Avec: Colin T Shearn , Blair Fennimore , David J Orlicky , Yue R Gao , Laura M Saba , Kayla D Battista , Stefanos Aivazidis , Mohammed Assiri , Peter S Harris , Cole Michel , Gary F Merrill , Edward E Schmidt , Sean P Colgan , Dennis R Petersen

Bile acids modulate colonic MAdCAM-1 expression in a murine model of combined cholestasis and colitis.

Mucosal immunology

Avec: Rachel Y Gao , Colin T Shearn , David J Orlicky , Kayla D Battista , Erica E Alexeev , Ian M Cartwright , Jordi M Lanis , Rachael E Kostelecky , Cynthia Ju , Sean P Colgan , Blair P Fennimore

4-Hydroxy-2-nonenal attenuates 8-oxoguanine DNA glycosylase 1 activity.

Journal of cellular biochemistry

Avec: Guodong Pan , Mandar Deshpande , Haiyan Pang , Paul M Stemmer , Nicholas J Carruthers , Colin T Shearn , Donald S Backos , Suresh S Palaniyandi

Quantifying Competition among Mitochondrial Protein Acylation Events Induced by Ethanol Metabolism.

Journal of proteome research

Avec: Hadi R Ali , Mohammed A Assiri , Peter S Harris , Cole R Michel , Youngho Yun , John O Marentette , Frank K Huynh , David J Orlicky , Colin T Shearn , Laura M Saba , Richard Reisdorph , Nichole Reisdorph , Matthew D Hirschey , Kristofer S Fritz

Supplemental Ascorbate Diminishes DNA Damage Yet Depletes Glutathione and Increases Acute Liver Failure in a Mouse Model of Hepatic Antioxidant System Disruption.

Antioxidants (Basel, Switzerland)

Avec: Colin G Miller , Jean A Kundert , Justin R Prigge , Julie A Amato , Allison E Perez , Lucia Coppo , Gabrielle N Rizzo , Michael P Kavanaugh , David J Orlicky , Colin T Shearn , Edward E Schmidt

NF-κB Regulation of LRH-1 and ABCG5/8 Potentiates Phytosterol Role in the Pathogenesis of Parenteral Nutrition-Associated Cholestasis.

Hepatology (Baltimore, Md.)

Avec: Swati Ghosh , Michael W Devereaux , Aimee L Anderson , Sarah Gehrke , Julie A Reisz , Angelo D'Alessandro , David J Orlicky , Mark Lovell , Karim C El Kasmi , Colin T Shearn , Ronald J Sokol

Thioredoxin reductase 1 regulates hepatic inflammation and macrophage activation during acute cholestatic liver injury.

Hepatology communications

Avec: Colin T Shearn , Aimee L Anderson , Colin G Miller , Reed C Noyd , Michael W Devereaux , Nata Balasubramaniyan , David J Orlicky , Edward E Schmidt , Ronald J Sokol

Lipid peroxidation derived reactive aldehydes in alcoholic liver disease.

Current opinion in toxicology

Avec: Hadi Ali , Mohammed A Assiri , Colin T Shearn , Kristofer S Fritz

TrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma malignancy.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Michael R McLoughlin , David J Orlicky , Justin R Prigge , Pushya Krishna , Emily A Talago , Ian R Cavigli , Sofi Eriksson , Colin G Miller , Jean A Kundert , Volkan I Sayin , Rachel A Sabol , Joshua Heinemann , Luke O Brandenberger , Sonya V Iverson , Brian Bothner , Thales Papagiannakopoulos , Colin T Shearn , Elias S J Arnér , Edward E Schmidt

Pharmacologic activation of hepatic farnesoid X receptor prevents parenteral nutrition-associated cholestasis in mice.

Hepatology (Baltimore, Md.)

Avec: Karim C El Kasmi , Swati Ghosh , Aimee L Anderson , Michael W Devereaux , Natarajan Balasubramaniyan , Angelo D'Alessandro , David J Orlicky , Frederick J Suchy , Colin T Shearn , Ronald J Sokol

Interrupting tumor necrosis factor-alpha signaling prevents parenteral nutrition-associated cholestasis in mice.

JPEN. Journal of parenteral and enteral nutrition

Avec: Karim C El Kasmi , Aimee L Anderson , Michael W Devereaux , Natarajan Balasubramaniyan , Frederick J Suchy , David J Orlicky , Colin T Shearn , Ronald J Sokol

The autophagic protein p62 is a target of reactive aldehydes in human and murine cholestatic liver disease.

PloS one

Avec: Colin T Shearn , Aimee L Anderson , Michael W Devereux , David J Orlicky , Cole Michel , Dennis R Petersen , Colin G Miller , Sanjiv Harpavat , Edward E Schmidt , Ronald J Sokol

Expression of circadian regulatory genes is dysregulated by increased cytokine production in mice subjected to concomitant intestinal injury and parenteral nutrition.

PloS one

Avec: Colin T Shearn , Aimee L Anderson , Michael W Devereaux , Karim C El Kasmi , David J Orlicky , Ronald J Sokol

Parenteral nutrition results in peripheral ileal to hepatic circadian discordance in mice.

American journal of physiology. Gastrointestinal and liver physiology

Avec: Colin T Shearn , Aimee L Anderson , Michael W Devereaux , Ronald J Sokol

Réseau de co-auteurs

David J Orlicky 13 collaborations

Aimee L Anderson 7 collaborations

Ronald J Sokol 7 collaborations

Michael W Devereaux 6 collaborations

Edward E Schmidt 5 collaborations

Colin G Miller 4 collaborations

Karim C El Kasmi 4 collaborations

Cole Michel 3 collaborations

Nichole Reisdorph 2 collaborations

Richard Reisdorph 2 collaborations

Georgia Charkoftaki 2 collaborations

Ying Chen 2 collaborations

Yewei Wang 2 collaborations

David C Thompson 2 collaborations

Vasilis Vasiliou 2 collaborations

Laura M Saba 2 collaborations

Kayla D Battista 2 collaborations

Peter S Harris 2 collaborations

Sean P Colgan 2 collaborations

Dennis R Petersen 2 collaborations

Mohammed A Assiri 2 collaborations

Kristofer S Fritz 2 collaborations

Jean A Kundert 2 collaborations

Justin R Prigge 2 collaborations

Swati Ghosh 2 collaborations

Angelo D'Alessandro 2 collaborations

Natarajan Balasubramaniyan 2 collaborations

Frederick J Suchy 2 collaborations

Aml A Alnaas 1 collaboration

Abena Watson-Siriboe 1 collaboration

Sherleen Tran 1 collaboration

Mikias Negussie 1 collaboration

Jack A Henderson 1 collaboration

J Ryan Osterberg 1 collaboration

Nara L Chon 1 collaboration

Beckston M Harrott 1 collaboration

Julianna Oviedo 1 collaboration

Tatyana Lyakhova 1 collaboration

Hai Lin 1 collaboration

Jefferson D Knight 1 collaboration

Jaya Prakash Golla 1 collaboration

Alvaro Santos-Neto 1 collaboration

Rolando Garcia-Milian 1 collaboration

Nicholas J W Rattray 1 collaboration

Yuping Cai 1 collaboration

Varvara Mironova 1 collaboration

Yensheng Wang 1 collaboration

Caroline H Johnson 1 collaboration

Emily A Davidson 1 collaboration

Surendra Singh 1 collaboration

Brian Thompson 1 collaboration

Tristan A Furnary 1 collaboration

Rebecca L Cardone 1 collaboration

Richard G Kibbey 1 collaboration

Daniel W Nebert 1 collaboration

Blair Fennimore 1 collaboration

Yue R Gao 1 collaboration

Stefanos Aivazidis 1 collaboration

Mohammed Assiri 1 collaboration

Gary F Merrill 1 collaboration

Rachel Y Gao 1 collaboration

Erica E Alexeev 1 collaboration

Ian M Cartwright 1 collaboration

Jordi M Lanis 1 collaboration

Rachael E Kostelecky 1 collaboration

Cynthia Ju 1 collaboration

Blair P Fennimore 1 collaboration

Guodong Pan 1 collaboration

Mandar Deshpande 1 collaboration

Haiyan Pang 1 collaboration

Paul M Stemmer 1 collaboration

Nicholas J Carruthers 1 collaboration

Donald S Backos 1 collaboration

Suresh S Palaniyandi 1 collaboration

Hadi R Ali 1 collaboration

Cole R Michel 1 collaboration

Youngho Yun 1 collaboration

John O Marentette 1 collaboration

Frank K Huynh 1 collaboration

Matthew D Hirschey 1 collaboration

Julie A Amato 1 collaboration

Allison E Perez 1 collaboration

Lucia Coppo 1 collaboration

Gabrielle N Rizzo 1 collaboration

Michael P Kavanaugh 1 collaboration

Sarah Gehrke 1 collaboration

Julie A Reisz 1 collaboration

Mark Lovell 1 collaboration

Reed C Noyd 1 collaboration

Nata Balasubramaniyan 1 collaboration

Hadi Ali 1 collaboration

Michael R McLoughlin 1 collaboration

Pushya Krishna 1 collaboration

Emily A Talago 1 collaboration

Ian R Cavigli 1 collaboration

Sofi Eriksson 1 collaboration

Volkan I Sayin 1 collaboration

Rachel A Sabol 1 collaboration

Joshua Heinemann 1 collaboration

Luke O Brandenberger 1 collaboration

Sonya V Iverson 1 collaboration

Brian Bothner 1 collaboration

Thales Papagiannakopoulos 1 collaboration

Elias S J Arnér 1 collaboration

Michael W Devereux 1 collaboration

Sanjiv Harpavat 1 collaboration