Effects of single and combined immunotherapy approach targeting amyloid β protein and α-synuclein in a dementia with Lewy bodies-like model.
AFFITOPE®
Alzheimer's disease
Dementia with Lewy bodies
Immunization
Immunotherapy
α-synuclein
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
24
10
2018
revised:
22
01
2019
accepted:
25
02
2019
pubmed:
6
8
2019
medline:
8
8
2020
entrez:
6
8
2019
Statut:
ppublish
Résumé
Immunotherapeutic approaches targeting amyloid β (Aβ) protein and tau in Alzheimer's disease and α-synuclein (α-syn) in Parkinson's disease are being developed for treating dementia with Lewy bodies. However, it is unknown if single or combined immunotherapies targeting Aβ and/or α-syn may be effective. Amyloid precursor protein/α-syn tg mice were immunized with AFFITOPEs® (AFF) peptides specific to Aβ (AD02) or α-syn (PD-AFF1) and the combination. AD02 more effectively reduced Aβ and pTau burden; however, the combination exhibited some additive effects. Both AD02 and PD-AFF1 effectively reduced α-syn, ameliorated degeneration of pyramidal neurons, and reduced neuroinflammation. PD-AFF1 more effectively ameliorated cholinergic and dopaminergic fiber loss; the combined immunization displayed additive effects. AD02 more effectively improved buried pellet test behavior, whereas PD-AFF1 more effectively improved horizontal beam test; the combined immunization displayed additive effects. Specific active immunotherapy targeting Aβ and/or α-syn may be of potential interest for the treatment of dementia with Lewy bodies.
Identifiants
pubmed: 31378574
pii: S1552-5260(19)30071-8
doi: 10.1016/j.jalz.2019.02.002
pmc: PMC7503212
mid: NIHMS1584449
pii:
doi:
Substances chimiques
Amyloid beta-Peptides
0
Immunologic Factors
0
alpha-Synuclein
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1133-1148Subventions
Organisme : NIA NIH HHS
ID : R21 AG051839
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005131
Pays : United States
Organisme : BLRD VA
ID : I01 BX003040
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG018440
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG010483
Pays : United States
Informations de copyright
Copyright © 2019. Published by Elsevier Inc.
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