Synthesis, molecular docking analysis and carbonic anhydrase I-II inhibitory evaluation of new sulfonamide derivatives.

Acetamides / chemical synthesis Animals Carbonic Anhydrase I / antagonists & inhibitors Carbonic Anhydrase II / antagonists & inhibitors Carbonic Anhydrase Inhibitors / chemical synthesis Humans Mice Molecular Docking Simulation Molecular Structure NIH 3T3 Cells Structure-Activity Relationship
ADME Carbonic anhydrase Cytotoxicity Molecular docking Sulfonamide

Journal

Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703

Informations de publication

Date de publication:
10 2019
Historique:
received: 26 12 2018
revised: 23 05 2019
accepted: 24 07 2019
pubmed: 6 8 2019
medline: 21 10 2020
entrez: 6 8 2019
Statut: ppublish

Résumé

New sulfonamide-hydrazone derivatives (3a-3n) were synthesized to evaluate their inhibitory effects on purified human carbonic anhydrase (hCA) I and II. The inhibition profiles of the synthesized compounds on hCA I-II isoenzyme were investigated by comparing their IC

Identifiants

DOI: 10.1016/j.bioorg.2019.103153 PMID: 31382057
pubmed: 31382057
pii: S0045-2068(18)31535-9
doi: 10.1016/j.bioorg.2019.103153
pii:
doi:

Substances chimiques

Acetamides 0
Carbonic Anhydrase Inhibitors 0
Carbonic Anhydrase I EC 4.2.1.-
Carbonic Anhydrase II EC 4.2.1.-

Types de publication

Evaluation Study Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

103153

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Begüm Nurpelin Sağlık (BN)

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey; Doping and Narcotic Compounds Analysis Laboratory, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey. Electronic address: bnsaglik@anadolu.edu.tr.

Ulviye Acar Çevik (UA)

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey; Doping and Narcotic Compounds Analysis Laboratory, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey.

Derya Osmaniye (D)

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey; Doping and Narcotic Compounds Analysis Laboratory, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey.

Serkan Levent (S)

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey; Doping and Narcotic Compounds Analysis Laboratory, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey.

Betul Kaya Çavuşoğlu (BK)

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey.

Yeliz Demir (Y)

Department of Pharmacy Services, Nihat Delibalta Göle Vocational High School, Ardahan University, 75700 Ardahan, Turkey.

Sinem Ilgın (S)

Department of Toxicology, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey.

Yusuf Özkay (Y)

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey; Doping and Narcotic Compounds Analysis Laboratory, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey.

Ali Savaş Koparal (AS)

Open Education Faculty, Anadolu University, 26470 Eskişehir, Turkey.

Şükrü Beydemir (Ş)

Department of Biochemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey.

Zafer Asım Kaplancıklı (ZA)

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey.

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides acycliques › Acétamides › Synthesis, molecular docking analysis and...
questionsmedicales.fr › Eucaryotes › Animaux › Synthesis, molecular docking analysis and...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Lyases › Carbon-oxygen lyases › Hydro-lyases › Carbonic anhydrases › Carbonic anhydrase I › Synthesis, molecular docking analysis and...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Lyases › Carbon-oxygen lyases › Hydro-lyases › Carbonic anhydrases › Carbonic anhydrase II › Synthesis, molecular docking analysis and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de l'anhydrase carbonique › Synthesis, molecular docking analysis and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Synthesis, molecular docking analysis and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Synthesis, molecular docking analysis and...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Synthesis, molecular docking analysis and...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Synthesis, molecular docking analysis and...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Fibroblastes › Cellules 3T3 › Cellules NIH 3T3 › Synthesis, molecular docking analysis and...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Synthesis, molecular docking analysis and...