Longitudinal cognitive decline in autosomal-dominant Alzheimer's disease varies with mutations in APP and PSEN1 genes.
APP
Alzheimer's disease
Autosomal dominant
Cognition
Longitudinal
PSEN1
Journal
Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
15
01
2019
revised:
16
06
2019
accepted:
28
06
2019
pubmed:
7
8
2019
medline:
26
6
2020
entrez:
7
8
2019
Statut:
ppublish
Résumé
The purpose was to compare longitudinal cognitive changes in APP and PSEN1 gene mutation carriers and noncarriers from four autosomal-dominant Alzheimer's disease (ADAD) families across preclinical and early clinical stages of disease. Carriers (n = 34) with four different mutations (PSEN1
Identifiants
pubmed: 31386938
pii: S0197-4580(19)30192-7
doi: 10.1016/j.neurobiolaging.2019.06.010
pii:
doi:
Substances chimiques
Amyloid beta-Protein Precursor
0
PSEN1 protein, human
0
Presenilin-1
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
40-47Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.