Antiviral activity of merimepodib against foot and mouth disease virus in vitro and in vivo.

Animals Antiviral Agents / pharmacology Carbamates / pharmacology Cell Line Foot-and-Mouth Disease / drug therapy Foot-and-Mouth Disease Virus / drug effects Mice Phenylurea Compounds / pharmacology Swine Viral Vaccines / pharmacology Virus Replication / drug effects
Antiviral activity FMDV In vivo Merimepodib

Journal

Molecular immunology
ISSN: 1872-9142
Titre abrégé: Mol Immunol
Pays: England
ID NLM: 7905289

Informations de publication

Date de publication:
10 2019
Historique:
received: 06 03 2019
revised: 04 05 2019
accepted: 25 07 2019
pubmed: 7 8 2019
medline: 22 1 2020
entrez: 7 8 2019
Statut: ppublish

Résumé

Foot and mouth disease virus (FMDV), a member of family Picornaviridae, belongs to the genus Aphthovirus, which causes foot and mouth disease (FMD), a highly transmissible disease that affects cloven-hoof animals. In spite of the fact that efficient vaccines are available, effective antiviral molecules for FMD are needed to reduce viral infection during early stages of infection. In this study, merimepodib was found to efficiently inhibit FMDV replication in a dose-dependent manner. The 50% inhibitory concentration (IC

Identifiants

DOI: 10.1016/j.molimm.2019.07.021 PMID: 31386979
pubmed: 31386979
pii: S0161-5890(19)30177-4
doi: 10.1016/j.molimm.2019.07.021
pii:
doi:

Substances chimiques

Antiviral Agents 0
Carbamates 0
N-3-(3-(3-methoxy-4-oxazol-5-ylphenyl)ureido)benzylcarbamic acid tetrahydrofuran-3-yl ester 0
Phenylurea Compounds 0
Viral Vaccines 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

226-232

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Shi-Fang Li (SF)

State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, Gansu, China.

Mei-Jiao Gong (MJ)

State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, Gansu, China.

Jun-Jun Shao (JJ)

State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, Gansu, China.

Yue-Feng Sun (YF)

State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, Gansu, China.

Yong-Guang Zhang (YG)

State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, Gansu, China.

Hui-Yun Chang (HY)

State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, Gansu, China. Electronic address: changhuiyun@caas.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Antiviral activity of merimepodib against foot...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Antiviral activity of merimepodib against foot...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides acycliques › Carbamates › Antiviral activity of merimepodib against foot...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Antiviral activity of merimepodib against foot...
questionsmedicales.fr › Maladies de l'animal › Fièvre aphteuse › Antiviral activity of merimepodib against foot...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Picornaviridae › Aphthovirus › Virus de la fièvre aphteuse › Antiviral activity of merimepodib against foot...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Antiviral activity of merimepodib against foot...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénylurées › Antiviral activity of merimepodib against foot...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Suidae › Antiviral activity of merimepodib against foot...
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Vaccins › Vaccins antiviraux › Antiviral activity of merimepodib against foot...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Réplication virale › Antiviral activity of merimepodib against foot...