The Activation Status of the TGF-β Transducer Smad2 Is Associated with a Reduced Survival in Gastrointestinal Cancers: A Systematic Review and Meta-Analysis.
Smad2
TGF-β
pSmad2
phosphorylation
signaling
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
05 Aug 2019
05 Aug 2019
Historique:
received:
09
07
2019
revised:
31
07
2019
accepted:
01
08
2019
entrez:
8
8
2019
pubmed:
8
8
2019
medline:
8
1
2020
Statut:
epublish
Résumé
Aberrant function of Smad2, a crucial member of transforming growth factor beta (TGF-β) signaling, is associated with the development of malignancies, particularly in the gastrointestinal district. However, little is known about its possible prognostic role in such tumor types. With the first meta-analysis on this topic, we demonstrated that the lack of the activated form of Smad2 (phosphor-Smad2 or pSmad2), which was meant to be the C-terminally phosphorylated form, showed a statistically significant association with an increased risk of all-cause mortality in patients with gastrointestinal cancers (RR, 1.58; 95% CI, 1.05-2.37,
Identifiants
pubmed: 31387321
pii: ijms20153831
doi: 10.3390/ijms20153831
pmc: PMC6695973
pii:
doi:
Substances chimiques
Biomarkers
0
SMAD2 protein, human
0
Smad2 Protein
0
Transforming Growth Factor beta
0
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Références
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