Free radicals, antioxidants, nuclear factor-E2-related factor-2 and liver damage.
Animals
Antioxidants
/ metabolism
Humans
Inflammation Mediators
/ metabolism
Liver
/ metabolism
Liver Diseases
/ epidemiology
NF-E2-Related Factor 2
/ metabolism
Nitrosative Stress
Oxidative Stress
Reactive Nitrogen Species
/ metabolism
Reactive Oxygen Species
/ metabolism
Risk Factors
Signal Transduction
NF-κB
Nrf2
fibrosis
inflammation
reactive oxygen species
Journal
Journal of applied toxicology : JAT
ISSN: 1099-1263
Titre abrégé: J Appl Toxicol
Pays: England
ID NLM: 8109495
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
07
06
2019
revised:
03
07
2019
accepted:
04
07
2019
pubmed:
8
8
2019
medline:
7
7
2021
entrez:
8
8
2019
Statut:
ppublish
Résumé
Oxidative/nitrosative stress is proposed to be a critical factor in various diseases, including liver pathologies. Antioxidants derived from medicinal plants have been studied extensively and are relevant to many illnesses, including liver diseases. Several hepatic disorders, such as viral hepatitis and alcoholic or nonalcoholic steatohepatitis, involve free radicals/oxidative stress as agents that cause or at least exacerbate liver injury, which can result in chronic liver diseases, such as liver fibrosis, cirrhosis and end-stage hepatocellular carcinoma. In this scenario, nuclear factor-E2-related factor-2 (Nrf2) appears to be an essential factor to counteract or attenuate oxidative or nitrosative stress in hepatic cells. In fact, a growing body of evidence indicates that Nrf2 plays complex and multicellular roles in hepatic inflammation, fibrosis, hepatocarcinogenesis and regeneration via the induction of its target genes. Inflammation is the most common feature of chronic liver diseases, triggering fibrosis, cirrhosis and hepatocellular carcinoma. Increasing evidence indicates that Nrf2 counteracts the proinflammatory process by modulating the recruitment of inflammatory cells and inducing the endogenous antioxidant response of the cell. In this review, the interactions between antioxidant and inflammatory molecular pathways are analyzed.
Substances chimiques
Antioxidants
0
Inflammation Mediators
0
NF-E2-Related Factor 2
0
Reactive Nitrogen Species
0
Reactive Oxygen Species
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
151-168Informations de copyright
© 2019 John Wiley & Sons, Ltd.
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