Bidirectional Cross-Talk between Biliary Epithelium and Th17 Cells Promotes Local Th17 Expansion and Bile Duct Proliferation in Biliary Liver Diseases.
Bile Ducts
/ pathology
Cell Communication
/ physiology
Cell Proliferation
Cells, Cultured
Epithelial Cells
/ physiology
Humans
Interleukin-17
/ pharmacology
Lipopolysaccharides
/ pharmacology
Liver Diseases
/ immunology
Receptors, Aryl Hydrocarbon
/ physiology
Receptors, CCR6
/ physiology
Th17 Cells
/ physiology
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
01 09 2019
01 09 2019
Historique:
received:
28
03
2018
accepted:
01
07
2019
pubmed:
9
8
2019
medline:
9
4
2020
entrez:
9
8
2019
Statut:
ppublish
Résumé
There is no effective treatment for autoimmune biliary diseases. Therefore, understanding their immunopathology is crucial. The biliary epithelial cells (BEC), expressing TLR-4, are constantly exposed to gut microbes and bacterial wall LPS, and in settings of inflammation, the immune infiltrate is dense within the peribiliary region of human liver. By dual immunohistochemistry, we affirm human intrahepatic T cell infiltrate includes CCR6
Identifiants
pubmed: 31391236
pii: jimmunol.1800455
doi: 10.4049/jimmunol.1800455
pmc: PMC6697739
doi:
Substances chimiques
CCR6 protein, human
0
Interleukin-17
0
Lipopolysaccharides
0
Receptors, Aryl Hydrocarbon
0
Receptors, CCR6
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1151-1159Subventions
Organisme : Medical Research Council
ID : MR/M009157/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0300101
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0300102
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0700301
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0802577
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_14123
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0400496
Pays : United Kingdom
Organisme : Medical Research Council
ID : G1002552
Pays : United Kingdom
Informations de copyright
Copyright © 2019 by The American Association of Immunologists, Inc.
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