Decreased bone mineral density and associated factors in severe haemophilia A patients: A case-control study.
bone mineral density
haemophilia
osteopenia
osteoporosis
Journal
Haemophilia : the official journal of the World Federation of Hemophilia
ISSN: 1365-2516
Titre abrégé: Haemophilia
Pays: England
ID NLM: 9442916
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
03
05
2019
revised:
17
07
2019
accepted:
18
07
2019
pubmed:
9
8
2019
medline:
8
2
2020
entrez:
9
8
2019
Statut:
ppublish
Résumé
Haemophilia patients may exhibit lower levels of bone mineral density (BMD) than the general population for a variety of reasons. We aimed to investigate decreased BMD in people with severe adult haemophilia A (PWH) living in eastern Turkey, and to evaluate the related potential risk factors. The study included 41 PWH and 40 healthy volunteers. Dual-energy x-ray absorptiometry (DXA) was used to measure the BMD. Blood tests and body mass index (BMI) were recorded. The Functional Independence Score in Hemophilia (FISH) test was used to measure functional ability status. There was a significant difference between the PWH and control groups with respect to femoral neck and total hip BMD (in g/cm The results indicated that the decrease in BMD was significantly greater in patients with severe haemophilia A than in the normal healthy population. This reduction was correlated with BMI, vitamin D and low functional ability status. However, in multivariate analysis, none of these was a strong independent risk factor.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e315-e321Subventions
Organisme : Yüzüncü Yıl University Scientific Research Project Committee
ID : THD-2018-6857
Informations de copyright
© 2019 John Wiley & Sons Ltd.
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