Antidepressant-Like Effect of Ferulic Acid via Promotion of Energy Metabolism Activity.
Animals
Antidepressive Agents
/ pharmacology
Behavior, Animal
/ drug effects
Brain-Derived Neurotrophic Factor
/ analysis
Cell Proliferation
/ drug effects
Coumaric Acids
/ pharmacology
Depression
/ drug therapy
Disease Models, Animal
Dopamine
/ analysis
Energy Metabolism
/ drug effects
Gene Expression
/ drug effects
Hindlimb Suspension
Limbic System
/ chemistry
Male
Mice
Mice, Inbred ICR
Signal Transduction
/ genetics
Depression
dopaminergic synapse
energy metabolism
ferulic acid
tail suspension test
Journal
Molecular nutrition & food research
ISSN: 1613-4133
Titre abrégé: Mol Nutr Food Res
Pays: Germany
ID NLM: 101231818
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
30
03
2019
revised:
07
06
2019
pubmed:
9
8
2019
medline:
23
6
2020
entrez:
9
8
2019
Statut:
ppublish
Résumé
Ferulic acid (FA), a natural phenolic phytochemical abundantly present in whole grains, herbs, and dried fruits, exhibits anti-inflammatory, antioxidant, and neuroprotective effects. In the present study, the antidepressant-like effects of FA in male ICR mice using tail suspension test (TST) are investigated and its molecular mechanisms are explored. Oral administration of FA at a dose of 5 mg kg The research provides the first evidence that FA enhances energy production, which can be the underlying mechanism of the antidepressant-like effects of FA observed in this study.
Identifiants
pubmed: 31394019
doi: 10.1002/mnfr.201900327
pmc: PMC6790570
doi:
Substances chimiques
Antidepressive Agents
0
Brain-Derived Neurotrophic Factor
0
Coumaric Acids
0
ferulic acid
AVM951ZWST
Dopamine
VTD58H1Z2X
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1900327Informations de copyright
© 2019 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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