Monitoring DNA-Ligand Interactions in Living Human Cells Using NMR Spectroscopy.

Anti-Infective Agents / chemistry Base Pairing / drug effects Binding Sites / drug effects Cell Line Cell Survival / drug effects DNA / chemistry Drug Discovery Humans Ligands Naphthalenes / chemistry Netropsin / chemistry Nuclear Magnetic Resonance, Biomolecular / methods Nucleic Acid Conformation / drug effects

Journal

Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056

Informations de publication

Date de publication:
28 08 2019
Historique:
pubmed: 10 8 2019
medline: 2 10 2020
entrez: 10 8 2019
Statut: ppublish

Résumé

Studies on DNA-ligand interactions in the cellular environment are problematic due to the lack of suitable biophysical tools. To address this need, we developed an

Identifiants

DOI: 10.1021/jacs.9b03031 PMID: 31394899
pubmed: 31394899
doi: 10.1021/jacs.9b03031
doi:

Substances chimiques

Anti-Infective Agents 0
Ligands 0
Naphthalenes 0
Netropsin 64B3O0RD7N
DNA 9007-49-2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

13281-13285

Auteurs

Michaela Krafcikova (M)

Central European Institute of Technology, Masaryk University , Brno 62500 , Czech Republic.
Institute of Biophysics , v.v.i., ASCR, Brno 62500 , Czech Republic.

Simon Dzatko (S)

Central European Institute of Technology, Masaryk University , Brno 62500 , Czech Republic.

Coralie Caron (C)

CNRS UMR9187, INSERM U1196, Institut Curie , PSL Research University , Orsay 91405 , France.
CNRS UMR9187, INSERM U1196, Université Paris Sud , Université Paris Saclay , Orsay 91405 , France.

Anton Granzhan (A)

CNRS UMR9187, INSERM U1196, Institut Curie , PSL Research University , Orsay 91405 , France.
CNRS UMR9187, INSERM U1196, Université Paris Sud , Université Paris Saclay , Orsay 91405 , France.
ORCID: 0000-0002-0424-0461

Radovan Fiala (R)

Central European Institute of Technology, Masaryk University , Brno 62500 , Czech Republic.

Tomas Loja (T)

Central European Institute of Technology, Masaryk University , Brno 62500 , Czech Republic.

Marie-Paule Teulade-Fichou (MP)

CNRS UMR9187, INSERM U1196, Institut Curie , PSL Research University , Orsay 91405 , France.
CNRS UMR9187, INSERM U1196, Université Paris Sud , Université Paris Saclay , Orsay 91405 , France.

Tomas Fessl (T)

Faculty of Science , University of South Bohemia , Ceske Budejovice CZ-370 05 , Czech Republic.

Robert Hänsel-Hertsch (R)

Cancer Research UK Cambridge Institute , University of Cambridge , Cambridge CB2 0RE , United Kingdom.

Jean-Louis Mergny (JL)

CNRS UMR9187, INSERM U1196, Institut Curie , PSL Research University , Orsay 91405 , France.
CNRS UMR9187, INSERM U1196, Université Paris Sud , Université Paris Saclay , Orsay 91405 , France.
Institute of Biophysics , v.v.i., ASCR, Brno 62500 , Czech Republic.
ORCID: 0000-0003-3043-8401

Silvie Foldynova-Trantirkova (S)

Institute of Biophysics , v.v.i., ASCR, Brno 62500 , Czech Republic.

Lukas Trantirek (L)

Central European Institute of Technology, Masaryk University , Brno 62500 , Czech Republic.
Institute of Biophysics , v.v.i., ASCR, Brno 62500 , Czech Republic.
ORCID: 0000-0001-5948-4837

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Monitoring DNA-Ligand Interactions in Living...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Conformation d'acide nucléique › Appariement de bases › Monitoring DNA-Ligand Interactions in Living...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Monitoring DNA-Ligand Interactions in Living...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Monitoring DNA-Ligand Interactions in Living...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Monitoring DNA-Ligand Interactions in Living...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › Monitoring DNA-Ligand Interactions in Living...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Monitoring DNA-Ligand Interactions in Living...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Monitoring DNA-Ligand Interactions in Living...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Monitoring DNA-Ligand Interactions in Living...
questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Naphtalènes › Monitoring DNA-Ligand Interactions in Living...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Oligopeptides › Nétropsine › Monitoring DNA-Ligand Interactions in Living...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › Résonance magnétique nucléaire biomoléculaire › Monitoring DNA-Ligand Interactions in Living...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Conformation d'acide nucléique › Monitoring DNA-Ligand Interactions in Living...