Indicators of mental disorders in UK Biobank-A comparison of approaches.
UK Biobank
cohort study
diagnosis
epidemiology
mental disorder
online survey
Journal
International journal of methods in psychiatric research
ISSN: 1557-0657
Titre abrégé: Int J Methods Psychiatr Res
Pays: United States
ID NLM: 9111433
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
04
10
2018
revised:
04
04
2019
accepted:
20
05
2019
pubmed:
10
8
2019
medline:
13
3
2020
entrez:
10
8
2019
Statut:
ppublish
Résumé
For many research cohorts, it is not practical to provide a "gold-standard" mental health diagnosis. It is therefore important for mental health research that potential alternative measures for ascertaining mental disorder status are understood. Data from UK Biobank in those participants who had completed the online Mental Health Questionnaire (n = 157,363) were used to compare the classification of mental disorder by four methods: symptom-based outcome (self-complete based on diagnostic interviews), self-reported diagnosis, hospital data linkage, and self-report medication. Participants self-reporting any psychiatric diagnosis had elevated risk of any symptom-based outcome. Cohen's κ between self-reported diagnosis and symptom-based outcome was 0.46 for depression, 0.28 for bipolar affective disorder, and 0.24 for anxiety. There were small numbers of participants uniquely identified by hospital data linkage and medication. Our results confirm that ascertainment of mental disorder diagnosis in large cohorts such as UK Biobank is complex. There may not be one method of classification that is right for all circumstances, but an informed and transparent use of outcome measure(s) to suit each research question will maximise the potential of UK Biobank and other resources for mental health research.
Identifiants
pubmed: 31397039
doi: 10.1002/mpr.1796
pmc: PMC6877131
doi:
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1796Subventions
Organisme : Wellcome Trust
ID : 104036/Z/14/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_17209
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Organisme : Chief Scientist Office
ID : DTF/14/03
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : The Sackler Trust
Pays : International
Informations de copyright
© 2019 The Authors International Journal of Methods in Psychiatric Research Published by John Wiley & Sons Ltd.
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