A Genetically Encoded, Phage-Displayed Cyclic-Peptide Library.
HDAC8
Nϵ-acryloyl-lysine
cyclic peptides
phage display
proximity-driven cyclization
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
28 10 2019
28 10 2019
Historique:
received:
17
07
2019
pubmed:
10
8
2019
medline:
20
9
2020
entrez:
10
8
2019
Statut:
ppublish
Résumé
Superior to linear peptides in biological activities, cyclic peptides are considered to have great potential as therapeutic agents. To identify cyclic-peptide ligands for therapeutic targets, phage-displayed peptide libraries in which cyclization is achieved by the covalent conjugation of cysteines have been widely used. To resolve drawbacks related to cysteine conjugation, we have invented a phage-display technique in which its displayed peptides are cyclized through a proximity-driven Michael addition reaction between a cysteine and an amber-codon-encoded N
Identifiants
pubmed: 31398275
doi: 10.1002/anie.201908713
pmc: PMC6803038
mid: NIHMS1046319
doi:
Substances chimiques
Ligands
0
Peptide Library
0
Peptides, Cyclic
0
Lysine
K3Z4F929H6
Cysteine
K848JZ4886
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
15904-15909Subventions
Organisme : Cancer Prevention and Research Institute of Texas
ID : RP170797
Pays : International
Organisme : NCI NIH HHS
ID : R01 CA161158
Pays : United States
Organisme : Welch Foundation
ID : A-1715
Pays : International
Informations de copyright
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
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