Cardiovascular Pleiotropic Effects of Natriuretic Peptides.
Atrial Natriuretic peptide
cardiac hypertrophy
cardiac remodelling
natriuretic peptides
vascular homeostasis.
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
08 Aug 2019
08 Aug 2019
Historique:
received:
28
06
2019
revised:
03
08
2019
accepted:
07
08
2019
entrez:
11
8
2019
pubmed:
11
8
2019
medline:
15
1
2020
Statut:
epublish
Résumé
Atrial natriuretic peptide (ANP) is a cardiac hormone belonging to the family of natriuretic peptides (NPs). ANP exerts diuretic, natriuretic, and vasodilatory effects that contribute to maintain water-salt balance and regulate blood pressure. Besides these systemic properties, ANP displays important pleiotropic effects in the heart and in the vascular system that are independent of blood pressure regulation. These functions occur through autocrine and paracrine mechanisms. Previous works examining the cardiac phenotype of loss-of-function mouse models of ANP signaling showed that both mice with gene deletion of ANP or its receptor natriuretic peptide receptor A (NPR-A) developed cardiac hypertrophy and dysfunction in response to pressure overload and chronic ischemic remodeling. Conversely, ANP administration has been shown to improve cardiac function in response to remodeling and reduces ischemia-reperfusion (I/R) injury. ANP also acts as a pro-angiogenetic, anti-inflammatory, and anti-atherosclerotic factor in the vascular system. Pleiotropic effects regarding brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP) were also reported. In this review, we discuss the current evidence underlying the pleiotropic effects of NPs, underlying their importance in cardiovascular homeostasis.
Identifiants
pubmed: 31398927
pii: ijms20163874
doi: 10.3390/ijms20163874
pmc: PMC6719167
pii:
doi:
Substances chimiques
Natriuretic Peptides
0
Natriuretic Peptide, Brain
114471-18-0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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