Structural and Functional Properties of the Capsid Protein of Dengue and Related
Dengue virus (DENV)
Flavivirus
capsid protein (C protein)
circular dichroism
intrinsically disordered protein (IDP)
protein–RNA interactions
protein–host lipid systems interaction
time-resolved fluorescence anisotropy
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
08 Aug 2019
08 Aug 2019
Historique:
received:
21
06
2019
revised:
05
08
2019
accepted:
06
08
2019
entrez:
11
8
2019
pubmed:
11
8
2019
medline:
15
1
2020
Statut:
epublish
Résumé
Dengue, West Nile and Zika, closely related viruses of the Flaviviridae family, are an increasing global threat, due to the expansion of their mosquito vectors. They present a very similar viral particle with an outer lipid bilayer containing two viral proteins and, within it, the nucleocapsid core. This core is composed by the viral RNA complexed with multiple copies of the capsid protein, a crucial structural protein that mediates not only viral assembly, but also encapsidation, by interacting with host lipid systems. The capsid is a homodimeric protein that contains a disordered N-terminal region, an intermediate flexible fold section and a very stable conserved fold region. Since a better understanding of its structure can give light into its biological activity, here, first, we compared and analyzed relevant mosquito-borne
Identifiants
pubmed: 31398956
pii: ijms20163870
doi: 10.3390/ijms20163870
pmc: PMC6720645
pii:
doi:
Substances chimiques
Capsid Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fundação para a Ciência e a Tecnologia
ID : Project PTDC/SAU-ENB/117013/2010
Organisme : Fundação para a Ciência e a Tecnologia
ID : Fellowship SFRH/BD/77609/2011
Organisme : Fundação para a Ciência e a Tecnologia
ID : Fellowship PD/BD/113698/2015
Organisme : Fundação para a Ciência e a Tecnologia
ID : Fellowship SFRH/BD/95856/2013
Organisme : Fundação Calouste Gulbenkian
ID : Project Science Frontiers Research Prize 2010
Organisme : Fundação para a Ciência e a Tecnologia
ID : Program Investigador FCT (IF/00772/2013)
Organisme : Fundação para a Ciência e a Tecnologia
ID : Program Concurso de Estímulo ao Emprego Científico (CEECIND/01670/2017)
Organisme : Fundação para a Ciência e a Tecnologia
ID : Project UID/BIM/50005/2019, Fundos do Orçamento do Estado
Déclaration de conflit d'intérêts
The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, and in the decision to publish the results.
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