c-Abl-Mediated Tyrosine Phosphorylation of PARP1 Is Crucial for Expression of Proinflammatory Genes.
Animals
Cell Line
DNA Damage
/ genetics
DNA Repair
/ genetics
Female
Gene Expression
/ genetics
Genes, abl
/ genetics
Humans
Inflammation
/ genetics
Macrophages
/ physiology
Mice
Mice, Inbred C57BL
NF-kappa B
/ genetics
Phosphorylation
/ genetics
Poly (ADP-Ribose) Polymerase-1
/ genetics
Protein Processing, Post-Translational
/ genetics
RAW 264.7 Cells
Signal Transduction
/ genetics
THP-1 Cells
Tyrosine
/ genetics
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
15 09 2019
15 09 2019
Historique:
received:
11
12
2018
accepted:
07
05
2019
pubmed:
11
8
2019
medline:
16
5
2020
entrez:
11
8
2019
Statut:
ppublish
Résumé
Poly(ADP-ribosyl)ation is a rapid and transient posttranslational protein modification mostly catalyzed by poly(ADP-ribose) polymerase-1 (PARP1). Fundamental roles of activated PARP1 in DNA damage repair and cellular response pathways are well established; however, the precise mechanisms by which PARP1 is activated independent of DNA damage, and thereby playing a role in expression of inflammatory genes, remain poorly understood. In this study, we show that, in response to LPS or TNF-α exposure, the nonreceptor tyrosine kinase c-Abl undergoes nuclear translocation and interacts with and phosphorylates PARP1 at the conserved Y829 site. Tyrosine-phosphorylated PARP1 is required for protein poly(ADP-ribosyl)ation of RelA/p65 and NF-κB-dependent expression of proinflammatory genes in murine RAW 264.7 macrophages, human monocytic THP1 cells, or mouse lungs. Furthermore, LPS-induced airway lung inflammation was reduced by inhibition of c-Abl activity. The present study elucidated a novel signaling pathway to activate PARP1 and regulate gene expression, suggesting that blocking the interaction of c-Abl with PARP1 or pharmaceutical inhibition of c-Abl may improve the outcomes of PARP1 activation-mediated inflammatory diseases.
Identifiants
pubmed: 31399520
pii: jimmunol.1801616
doi: 10.4049/jimmunol.1801616
pmc: PMC6731455
mid: NIHMS1529238
doi:
Substances chimiques
NF-kappa B
0
Tyrosine
42HK56048U
Parp1 protein, mouse
EC 2.4.2.30
Poly (ADP-Ribose) Polymerase-1
EC 2.4.2.30
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1521-1531Subventions
Organisme : NIAID NIH HHS
ID : P01 AI062885
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES018948
Pays : United States
Informations de copyright
Copyright © 2019 by The American Association of Immunologists, Inc.
Références
J Biol Chem. 2002 Oct 18;277(42):39066-9
pubmed: 12205080
Pharmacol Rev. 2002 Sep;54(3):375-429
pubmed: 12223530
Cell Mol Life Sci. 2002 Sep;59(9):1534-53
pubmed: 12440774
Science. 2003 Jan 24;299(5606):560-2
pubmed: 12543974
J Immunol. 2003 Feb 15;170(4):2113-20
pubmed: 12574383
Biochem Pharmacol. 2003 Apr 15;65(8):1373-82
pubmed: 12694878
Cell. 2003 Jun 13;113(6):677-83
pubmed: 12809599
J Cell Biochem. 2005 Feb 1;94(2):365-73
pubmed: 15526280
Prog Biophys Mol Biol. 2005 May;88(1):143-72
pubmed: 15561303
J Biol Chem. 2005 Apr 29;280(17):17076-83
pubmed: 15737996
J Mol Biol. 2005 May 6;348(3):609-15
pubmed: 15826658
Cell Mol Life Sci. 2005 Apr;62(7-8):739-50
pubmed: 15868399
Cell Mol Life Sci. 2005 Apr;62(7-8):751-9
pubmed: 15868400
Pharmacol Res. 2005 Jul;52(1):83-92
pubmed: 15911336
Biochem Cell Biol. 2005 Jun;83(3):354-64
pubmed: 15959561
Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W226-9
pubmed: 15980458
J Clin Invest. 2005 Oct;115(10):2731-41
pubmed: 16184194
Cell Immunol. 2005 Sep;237(1):1-6
pubmed: 16289055
Proc Natl Acad Sci U S A. 2006 May 2;103(18):7136-41
pubmed: 16627622
Nat Rev Mol Cell Biol. 2006 Jul;7(7):517-28
pubmed: 16829982
J Biochem. 2006 Aug;140(2):229-35
pubmed: 16840500
Clin Exp Immunol. 2007 Jan;147(1):164-75
pubmed: 17177976
Mol Cell. 2007 Jan 26;25(2):297-308
pubmed: 17244536
Eur J Immunol. 2007 Nov;37(11):3246-58
pubmed: 17960665
J Biol Chem. 2008 Jan 11;283(2):1197-208
pubmed: 18025084
FEBS Lett. 2008 May 28;582(12):1672-8
pubmed: 18439913
Hum Immunol. 2008 Aug;69(8):501-9
pubmed: 18619508
J Proteome Res. 2009 Feb;8(2):1014-29
pubmed: 19105632
J Immunol. 2009 Mar 1;182(5):3233-42
pubmed: 19234221
Immunol Rev. 2009 Mar;228(1):170-83
pubmed: 19290927
J Immunol. 2009 Jun 1;182(11):7297-306
pubmed: 19454727
Autoimmunity. 2010 Feb;43(1):48-55
pubmed: 20001666
Biochem Biophys Res Commun. 2010 Feb 26;393(1):123-5
pubmed: 20122899
J Biol Chem. 2010 Apr 9;285(15):11596-606
pubmed: 20145242
Mol Immunol. 2010 Apr;47(7-8):1492-9
pubmed: 20171739
Sci Signal. 2010 Sep 14;3(139):re6
pubmed: 20841568
Am J Pathol. 2011 Mar;178(3):946-55
pubmed: 21356345
Biochem Pharmacol. 2011 Nov 15;82(10):1269-76
pubmed: 21763684
N Biotechnol. 2012 Jun 15;29(5):571-7
pubmed: 22178400
Hum Immunol. 2012 May;73(5):439-47
pubmed: 22391342
Genes Dev. 2012 Mar 1;26(5):417-32
pubmed: 22391446
Science. 2012 May 11;336(6082):728-32
pubmed: 22582261
Genes Dev. 2012 Sep 1;26(17):1972-83
pubmed: 22948662
Genes Cancer. 2012 May;3(5-6):436-46
pubmed: 23226581
J Leukoc Biol. 2013 Apr;93(4):611-22
pubmed: 23325923
Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3161-6
pubmed: 23382195
Crit Care. 2013 Jun 20;17(3):R114
pubmed: 23787115
Int J Biochem Cell Biol. 2013 Dec;45(12):2764-73
pubmed: 24055812
Mol Cell Biol. 2014 Apr;34(7):1188-97
pubmed: 24421390
Acta Pharmacol Sin. 2014 Apr;35(4):496-503
pubmed: 24632845
J Immunol. 2014 Nov 1;193(9):4643-53
pubmed: 25267977
Am J Physiol Lung Cell Mol Physiol. 2015 May 15;308(10):L1025-38
pubmed: 25795725
J Biol Chem. 2015 Nov 27;290(48):28675-82
pubmed: 26429911
J Neuroinflammation. 2015 Dec 04;12:229
pubmed: 26637332
Nat Med. 2016 Feb;22(2):194-201
pubmed: 26779812
PLoS One. 2016 Mar 17;11(3):e0151845
pubmed: 26986624
Genes Dev. 2017 Jan 15;31(2):101-126
pubmed: 28202539
Nat Commun. 2017 Mar 31;8:15191
pubmed: 28361873
Front Biosci (Landmark Ed). 2018 Jan 1;23:13-26
pubmed: 28930534
Science. 2018 Nov 16;362(6416):834-839
pubmed: 30442810
N Engl J Med. 1993 May 20;328(20):1471-7
pubmed: 8479467
J Immunol. 1998 Apr 1;160(7):3330-6
pubmed: 9531291