Prevalence estimates for pyoderma gangrenosum in the United States: An age- and sex-adjusted population analysis.
Adolescent
Adult
Age Distribution
Age Factors
Aged
Aged, 80 and over
Bias
Cost of Illness
Cross-Sectional Studies
Electronic Health Records
/ statistics & numerical data
Female
Humans
Male
Middle Aged
Prevalence
Pyoderma Gangrenosum
/ epidemiology
Risk Factors
Sex Distribution
Sex Factors
United States
/ epidemiology
Young Adult
epidemiology
female
prevalence
pyoderma gangrenosum
Journal
Journal of the American Academy of Dermatology
ISSN: 1097-6787
Titre abrégé: J Am Acad Dermatol
Pays: United States
ID NLM: 7907132
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
14
06
2019
revised:
24
07
2019
accepted:
02
08
2019
pubmed:
11
8
2019
medline:
25
2
2021
entrez:
11
8
2019
Statut:
ppublish
Résumé
The disease burden of pyoderma gangrenosum (PG) is poorly understood. To determine standardized overall and age-, sex-, and race-specific prevalence estimates for PG among adults in the United States. Cross-sectional analysis of 1971 patients with PG identified using electronic health records data from a diverse population-based sample of more than 58 million patients. The age- and sex-standardized prevalence of PG among the study population was 0.0058%, or 5.8 PG cases (95% confidence interval [CI], 5.6-6.1) per 100,000 adults. Adjusted prevalence was nearly twice as high among women (7.1 cases [95% CI, 6.7-7.5] per 100,000) than men (4.4 cases [95% CI, 4.0-4.7] per 100,000). Patients between the ages of 70 and 79 years had the highest standardized prevalence (9.8 cases [95% CI, 8.8-10.9] per 100,000), with patients aged ≥50 years representing nearly 70% of all PG cases. Standardized prevalence was similar among white and African American patients. The female-to-male ratio of PG was >1.8 across all age groups. Analysis of electronic health records data may result in misclassification bias. PG is a rare disease that most commonly affects women and those aged ≥50 years.
Sections du résumé
BACKGROUND
BACKGROUND
The disease burden of pyoderma gangrenosum (PG) is poorly understood.
OBJECTIVE
OBJECTIVE
To determine standardized overall and age-, sex-, and race-specific prevalence estimates for PG among adults in the United States.
METHODS
METHODS
Cross-sectional analysis of 1971 patients with PG identified using electronic health records data from a diverse population-based sample of more than 58 million patients.
RESULTS
RESULTS
The age- and sex-standardized prevalence of PG among the study population was 0.0058%, or 5.8 PG cases (95% confidence interval [CI], 5.6-6.1) per 100,000 adults. Adjusted prevalence was nearly twice as high among women (7.1 cases [95% CI, 6.7-7.5] per 100,000) than men (4.4 cases [95% CI, 4.0-4.7] per 100,000). Patients between the ages of 70 and 79 years had the highest standardized prevalence (9.8 cases [95% CI, 8.8-10.9] per 100,000), with patients aged ≥50 years representing nearly 70% of all PG cases. Standardized prevalence was similar among white and African American patients. The female-to-male ratio of PG was >1.8 across all age groups.
LIMITATIONS
CONCLUSIONS
Analysis of electronic health records data may result in misclassification bias.
CONCLUSION
CONCLUSIONS
PG is a rare disease that most commonly affects women and those aged ≥50 years.
Identifiants
pubmed: 31400451
pii: S0190-9622(19)32494-6
doi: 10.1016/j.jaad.2019.08.001
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
425-429Informations de copyright
Copyright © 2019 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.