Children's exposure to phthalates and non-phthalate plasticizers in the home: The TESIE study.
Journal
Environment international
ISSN: 1873-6750
Titre abrégé: Environ Int
Pays: Netherlands
ID NLM: 7807270
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
05
06
2019
revised:
25
07
2019
accepted:
25
07
2019
pubmed:
11
8
2019
medline:
5
3
2020
entrez:
11
8
2019
Statut:
ppublish
Résumé
Phthalates and their potential replacements, including non-phthalate plasticizers, are ubiquitous in home environments due to their presence in building materials, plastics, and personal care products. As a result, exposure to these compounds is universal. However, the primary pathways of exposure and understanding which products in the home are associated most strongly with particular exposures are unclear. We sought to investigate the relationships between phthalates and non-phthalate plasticizers in paired samples of house dust, hand wipes, and their corresponding metabolites in children's urine samples (n = 180). In addition, we compared product use or presence of materials in the household against all compounds to investigate the relationship between product use or presence and exposure. Children aged 3-6 years provided hand wipe and urine samples. Questionnaires were completed by mothers or legal guardians to capture product use and housing characteristics, and house dust samples were collected from the main living area during home visits. Phthalates and non-phthalate replacements were detected frequently in the environmental matrices. All urine samples had at least 13 of 19 phthalate or non-phthalate replacement metabolites present. Hand wipe mass and dust concentrations of diisobutyl phthalate, benzyl butyl phthalate (BBP), bis(2-ethylhexyl) phthalate, and di-isononyl phthalate were significantly associated with their corresponding urinary metabolites (r This paper summarizes one of the most comprehensive phthalate and non-phthalate plasticizer investigation of potential residential exposure sources conducted in North America to date. The data presented herein provide evidence that dermal contact and hand-to-mouth behaviors are important sources of exposure to phthalates and non-phthalate plasticizers. In addition, the percentage of vinyl flooring is an important consideration when examining residential exposures to these compounds.
Sections du résumé
BACKGROUND
Phthalates and their potential replacements, including non-phthalate plasticizers, are ubiquitous in home environments due to their presence in building materials, plastics, and personal care products. As a result, exposure to these compounds is universal. However, the primary pathways of exposure and understanding which products in the home are associated most strongly with particular exposures are unclear.
OBJECTIVES
We sought to investigate the relationships between phthalates and non-phthalate plasticizers in paired samples of house dust, hand wipes, and their corresponding metabolites in children's urine samples (n = 180). In addition, we compared product use or presence of materials in the household against all compounds to investigate the relationship between product use or presence and exposure.
METHODS
Children aged 3-6 years provided hand wipe and urine samples. Questionnaires were completed by mothers or legal guardians to capture product use and housing characteristics, and house dust samples were collected from the main living area during home visits.
RESULTS
Phthalates and non-phthalate replacements were detected frequently in the environmental matrices. All urine samples had at least 13 of 19 phthalate or non-phthalate replacement metabolites present. Hand wipe mass and dust concentrations of diisobutyl phthalate, benzyl butyl phthalate (BBP), bis(2-ethylhexyl) phthalate, and di-isononyl phthalate were significantly associated with their corresponding urinary metabolites (r
CONCLUSIONS
This paper summarizes one of the most comprehensive phthalate and non-phthalate plasticizer investigation of potential residential exposure sources conducted in North America to date. The data presented herein provide evidence that dermal contact and hand-to-mouth behaviors are important sources of exposure to phthalates and non-phthalate plasticizers. In addition, the percentage of vinyl flooring is an important consideration when examining residential exposures to these compounds.
Identifiants
pubmed: 31400598
pii: S0160-4120(19)31909-9
doi: 10.1016/j.envint.2019.105061
pmc: PMC7511177
mid: NIHMS1630511
pii:
doi:
Substances chimiques
Cosmetics
0
Dust
0
Environmental Pollutants
0
Phthalic Acids
0
Plasticizers
0
Vinyl Compounds
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
105061Subventions
Organisme : NIEHS NIH HHS
ID : R01 ES016099
Pays : United States
Organisme : NIEHS NIH HHS
ID : T32 ES021432
Pays : United States
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.
Références
Environ Sci Technol. 2009 Apr 1;43(7):2374-80
pubmed: 19452889
Environ Health Perspect. 2012 Jul;120(7):1049-54
pubmed: 22763040
Chemosphere. 2018 Jul;203:44-53
pubmed: 29605748
J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Aug 15;1092:473-479
pubmed: 30008303
Environ Sci Technol. 2016 Oct 4;50(19):10661-10672
pubmed: 27623734
Am Ind Hyg Assoc J. 1993 Oct;54(10):615-27
pubmed: 8237794
Adv Nutr. 2019 Sep 1;10(5):803-815
pubmed: 31144713
Environ Health Perspect. 2010 Feb;118(2):253-8
pubmed: 20123613
Epidemiology. 1990 Jan;1(1):43-6
pubmed: 2081237
Environ Sci Technol. 2008 May 1;42(9):3329-34
pubmed: 18522114
Int J Hyg Environ Health. 2017 Mar;220(2 Pt A):55-63
pubmed: 27789189
Indoor Air. 2019 Jan;29(1):43-54
pubmed: 30240038
Environ Sci Technol. 2011 Apr 15;45(8):3788-94
pubmed: 21434628
Chemosphere. 2018 Jul;203:336-344
pubmed: 29626811
Environ Sci Technol. 2008 May 15;42(10):3732-8
pubmed: 18546715
Int J Androl. 2006 Feb;29(1):134-9; discussion 181-5
pubmed: 16466533
Environ Int. 2018 Jul;116:176-185
pubmed: 29689464
Environ Sci Technol. 2015 Aug 18;49(16):9674-81
pubmed: 26200125
Environ Sci Technol. 2014 Jul 1;48(13):7428-35
pubmed: 24911978
Environ Int. 2013 Nov;61:64-72
pubmed: 24103347
Environ Int. 2018 Oct;119:26-36
pubmed: 29929048
Indoor Air. 2015 Dec;25(6):572-81
pubmed: 25557639
Indoor Air. 2012 Oct;22(5):356-77
pubmed: 22313149
Chemosphere. 2000 Nov;41(9):1389-99
pubmed: 11057575
J Expo Sci Environ Epidemiol. 2013 Mar;23(2):197-206
pubmed: 23168567
Sci Total Environ. 2017 Dec 1;599-600:1984-1992
pubmed: 28558421
PLoS One. 2013 Apr 23;8(4):e62442
pubmed: 23626820
Int J Hyg Environ Health. 2011 Jan;214(1):26-35
pubmed: 20851676
Sci Total Environ. 2019 Jan 15;648:135-143
pubmed: 30114584
Environ Int. 2018 Dec;121(Pt 1):916-930
pubmed: 30347374
Indoor Air. 2016 Jun;26(3):414-25
pubmed: 25929991
Environ Int. 2019 Feb;123:141-147
pubmed: 30529838
Environ Health Perspect. 2010 Jul;118(7):998-1003
pubmed: 20392686
Int J Hyg Environ Health. 2014 Jan;217(1):78-87
pubmed: 23623597
Arch Toxicol. 2017 Oct;91(10):3287-3291
pubmed: 28314884
J Chromatogr A. 2014 Apr 4;1336:101-11
pubmed: 24598454
Anal Bioanal Chem. 2012 Jan;402(1):51-9
pubmed: 22065343
Environ Health. 2014 Jun 02;13(1):43
pubmed: 24894065
Environ Res. 2010 May;110(4):375-82
pubmed: 20227070
Am J Respir Crit Care Med. 2012 Nov 1;186(9):830-7
pubmed: 22923660
Food Chem Toxicol. 2001 Feb;39(2):97-108
pubmed: 11267702
Arch Toxicol. 2012 Dec;86(12):1829-39
pubmed: 22820759
BMC Public Health. 2011 Jan 21;11(1):46
pubmed: 21255390
Environ Pollut. 2017 Nov;230:701-708
pubmed: 28728088
Environ Res. 2015 Jul;140:369-76
pubmed: 25929801
Indoor Air. 2011 Feb;21(1):67-76
pubmed: 21054550
J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Dec 1;860(1):106-12
pubmed: 17997365
Environ Int. 2017 May;102:114-124
pubmed: 28274486