The new entries in the therapeutic armamentarium: The small molecule JAK inhibitors.
Baricitinib
JAK inhibitors
Rheumatic disease
Tofacitinib
Upadacitinib
Journal
Pharmacological research
ISSN: 1096-1186
Titre abrégé: Pharmacol Res
Pays: Netherlands
ID NLM: 8907422
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
06
06
2019
revised:
07
08
2019
accepted:
07
08
2019
pubmed:
12
8
2019
medline:
18
6
2020
entrez:
12
8
2019
Statut:
ppublish
Résumé
The past decade has witnessed an explosion in trial data on JAK inhibitors (JAKi). These small molecules target the Janus kinase - signal transducer and activator of transcription (JAK-STAT) pathway, blocking crucial cytokines across a septum of rheumatic diseases. As a class, JAKi are beginning to demonstrate efficacy on par, if not superior to biologics. Two first generation JAKi are licensed for use in inflammatory arthritis; tofacitinib and baricitinib. Next-generation JAKi have been designed with selective affinity for one JAK enzymes, the aim to reduce unwanted adverse effects without declining clinical efficacy. Emerging data with selective JAK1 inhibitors upadacitinib and filgotinib looks very promising. Despite differences in selectivity between JAKi, an overlap exists in their safety profiles. Across the class, a characteristic safety signal is emerging with viral opportunistic infections, particularly herpes zoster. Post marketing drug surveillance will be essential in evaluating the long-term risk with these agents.
Identifiants
pubmed: 31401212
pii: S1043-6618(19)31022-9
doi: 10.1016/j.phrs.2019.104392
pmc: PMC6876279
pii:
doi:
Substances chimiques
Antirheumatic Agents
0
Janus Kinase Inhibitors
0
STAT Transcription Factors
0
Janus Kinases
EC 2.7.10.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
104392Subventions
Organisme : Medical Research Council
ID : MR/R001332/1
Pays : United Kingdom
Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.
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