High-resolution intravascular MRI-guided perivascular ultrasound ablation.
Animals
Blood Vessels
/ diagnostic imaging
Chickens
High-Intensity Focused Ultrasound Ablation
In Vitro Techniques
Liver
/ diagnostic imaging
Magnetic Resonance Imaging
Muscle, Skeletal
/ diagnostic imaging
Psoas Muscles
/ diagnostic imaging
Swine
Temperature
Thermometry
Vena Cava, Inferior
/ diagnostic imaging
MR-guided ultrasound ablation
high intensity focused ultrasound (HIFU)
intravascular MRI (IVMRI)
liver and pancreatic cancer
vessel involvement
Journal
Magnetic resonance in medicine
ISSN: 1522-2594
Titre abrégé: Magn Reson Med
Pays: United States
ID NLM: 8505245
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
22
04
2019
revised:
24
06
2019
accepted:
15
07
2019
pubmed:
14
8
2019
medline:
3
2
2021
entrez:
13
8
2019
Statut:
ppublish
Résumé
To develop and test in animal studies ex vivo and in vivo, an intravascular (IV) MRI-guided high-intensity focused ultrasound (HIFU) ablation method for targeting perivascular pathology with minimal injury to the vessel wall. IV-MRI antennas were combined with 2- to 4-mm diameter water-cooled IV-ultrasound ablation catheters for IV-MRI on a 3T clinical MRI scanner. A software interface was developed for monitoring thermal dose with real-time MRI thermometry, and an MRI-guided ablation protocol developed by repeat testing on muscle and liver tissue ex vivo. MRI thermal dose was measured as cumulative equivalent minutes at 43°C (CEM Ex vivo experiments yielded a 6-min ablation protocol with the IV-ultrasound catheter coolant at 3-4°C, a 30 mL/min flow rate, and 7 W ablation power. In 8 experiments, 5- to 10-mm thick thermal lesions of area 0.5-2 cm IV-MRI-guided, IV-HIFU has potential as a precision treatment option that could preserve critical blood vessel wall during ablation of nonresectable perivascular tumors or other pathologies.
Identifiants
pubmed: 31402512
doi: 10.1002/mrm.27932
pmc: PMC6778713
mid: NIHMS1042696
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
240-253Subventions
Organisme : NIBIB NIH HHS
ID : R01 EB007829
Pays : United States
Informations de copyright
© 2019 International Society for Magnetic Resonance in Medicine.
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