Serum d- and l-lactate, pyruvate and glucose levels in individuals with at-risk mental state and correlations with clinical symptoms.
l-lactate
at-risk mental state
glucose
pyruvate
schizophrenia
Journal
Early intervention in psychiatry
ISSN: 1751-7893
Titre abrégé: Early Interv Psychiatry
Pays: Australia
ID NLM: 101320027
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
30
01
2019
revised:
31
05
2019
accepted:
14
07
2019
pubmed:
14
8
2019
medline:
7
2
2021
entrez:
13
8
2019
Statut:
ppublish
Résumé
Little information exists on the peripheral metabolite levels in individuals with at-risk mental state who meet the criteria for a high-risk state of psychosis. Here, we aimed to investigate serum levels of glucose, pyruvate and d- and l-lactate, which may act as a signalling molecule for learning and memory in neuronal cells. High performance liquid chromatography or commercial kits were used to assess serum metabolites in individuals with attenuated psychosis symptoms of at-risk mental state (n = 24, men = 12) who were not receiving antipsychotics. The metabolite levels of these individuals were compared with those of age- and sex-matched healthy individuals (controls, n = 23, men = 11). Correlations between the metabolites and clinical symptoms of at-risk mental state were also examined. Individuals with at-risk mental state had higher serum glucose levels than did controls (P = 2.18 × 10 We found that, compared with controls, individuals with at-risk mental state have reduced serum l-lactate levels, which may predate psychosis onset, and may be involved in the related negative symptoms.
Substances chimiques
Blood Glucose
0
Lactates
0
Pyruvic Acid
8558G7RUTR
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
410-417Subventions
Organisme : Japan Society for the Promotion of Science (JSPS) Grant-in-Aid for Scientific Research (C)
ID : 16K08944
Pays : International
Organisme : Toho University Joint Research Fund
Pays : International
Organisme : Inokashira Hospital Grants for Psychiatry Research
Pays : International
Informations de copyright
© 2019 John Wiley & Sons Australia, Ltd.
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