Understanding white matter structural connectivity differences between cognitively impaired and nonimpaired active professional fighters.
Adult
Athletes
Cognition
/ physiology
Cognitive Dysfunction
/ diagnostic imaging
Diffusion Magnetic Resonance Imaging
Female
Humans
Male
Nerve Net
/ diagnostic imaging
Neural Pathways
/ diagnostic imaging
Neuropsychological Tests
Psychomotor Performance
/ physiology
Reaction Time
/ physiology
White Matter
/ diagnostic imaging
Young Adult
DTI
RHI
cognitive impairment
graph-theoretical analysis
repeated head impacts
rich-club analysis
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
01 12 2019
01 12 2019
Historique:
received:
23
03
2019
revised:
20
07
2019
accepted:
31
07
2019
pubmed:
14
8
2019
medline:
17
4
2020
entrez:
13
8
2019
Statut:
ppublish
Résumé
Long-term traumatic brain injury due to repeated head impacts (RHI) has been shown to be a risk factor for neurodegenerative disorders, characterized by a loss in cognitive performance. Establishing the correlation between changes in the white matter (WM) structural connectivity measures and neuropsychological test scores might help to identify the neural correlates of the scores that are used in daily clinical setting to investigate deficits due to repeated head blows. Hence, in this study, we utilized high angular diffusion MRI (dMRI) of 69 cognitively impaired and 70 nonimpaired active professional fighters from the Professional Fighters Brain Health Study, and constructed structural connectomes to understand: (a) whether there is a difference in the topological WM organization between cognitively impaired and nonimpaired active professional fighters, and (b) whether graph-theoretical measures exhibit correlations with neuropsychological scores in these groups. A dMRI derived structural connectome was constructed for every participant using brain regions defined in AAL atlas as nodes, and the product of fiber number and average fractional anisotropy of the tracts connecting the nodes as edges. Our study identified a topological WM reorganization due to RHI in fighters prone to cognitive decline that was correlated with neuropsychological scores. Furthermore, graph-theoretical measures were correlated differentially with neuropsychological scores between groups. We also found differentiated WM connectivity involving regions of hippocampus, precuneus, and insula within our cohort of cognitively impaired fighters suggesting that there is a discernible WM topological reorganization in fighters prone to cognitive decline.
Identifiants
pubmed: 31403734
doi: 10.1002/hbm.24761
pmc: PMC6865667
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5108-5122Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM109025
Pays : United States
Organisme : The Peter and Angela Dal Pezzo funds
Pays : International
Organisme : The KMA Young Scientist Award
Pays : International
Organisme : Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health
ID : 5P20GM109025
Pays : International
Informations de copyright
© 2019 Wiley Periodicals, Inc.
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