Glucose and glycogen in the diabetic kidney: Heroes or villains?
Diabetes
Glucose
Glycogen
Glycogen storage disease
Kidney disease
Journal
EBioMedicine
ISSN: 2352-3964
Titre abrégé: EBioMedicine
Pays: Netherlands
ID NLM: 101647039
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
03
06
2019
revised:
17
07
2019
accepted:
29
07
2019
pubmed:
14
8
2019
medline:
6
2
2020
entrez:
14
8
2019
Statut:
ppublish
Résumé
Glucose metabolism in the kidney is currently foremost in the minds of nephrologists, diabetologists and researchers globally, as a result of the outstanding success of SGLT2 inhibitors in reducing renal and cardiovascular disease in individuals with diabetes. However, these exciting data have come with the puzzling but fascinating paradigm that many of the beneficial effects on the kidney and cardiovascular system seem to be independent of the systemic glucose lowering actions of these agents. This manuscript places into context an area of research highly relevant to renal glucose metabolism, that of glycogen accumulation and metabolism in the diabetic kidney. Whether the glycogen that abnormally accumulates is pathological (the villain), is somehow protective (the hero) or is inconsequential (the bystander) is a research question that may provide insight into the link between diabetes and diabetic kidney disease.
Identifiants
pubmed: 31405756
pii: S2352-3964(19)30509-2
doi: 10.1016/j.ebiom.2019.07.067
pmc: PMC6796499
pii:
doi:
Substances chimiques
Biomarkers
0
Blood Glucose
0
Glycogen
9005-79-2
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
590-597Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.
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