(15)O-H(2)O
(18)F-AV45
(18)F-FDG
Alzheimer's disease
Cerebral blood flow
Dual-phase PET
Early-phase PET
Perfusion imaging
R1
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
07
02
2019
revised:
27
04
2019
accepted:
21
05
2019
pubmed:
14
8
2019
medline:
8
8
2020
entrez:
14
8
2019
Statut:
ppublish
Résumé
Dual-biomarker positron emission tomography (PET), providing complementary information on cerebral blood flow and amyloid-β deposition, is of clinical interest for Alzheimer's disease (AD). The purpose of this study was to validate the perfusion components of early-phase This study included ten controls, 19 amnestic mild cognitive impairment, and 10 AD dementia subjects. Within-subject regional correlations between modalities, between-group regional and voxel-wise analyses of covariance per modality, and receiver operating characteristic analyses for discrimination between groups were performed. FDG standardized uptake value ratio, eAV45 (0-2 min) standardized uptake value ratio, and AV45-R1 were significantly associated with H R1 is preferable over eAV45 for accurate representation of brain perfusion in dual-biomarker PET for AD.
Identifiants
pubmed: 31405824
pii: S1552-5260(19)30151-7
doi: 10.1016/j.jalz.2019.05.010
pii:
doi:
Substances chimiques
Aniline Compounds
0
Ethylene Glycols
0
Fluorodeoxyglucose F18
0Z5B2CJX4D
florbetapir
6867Q6IKOD
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Validation Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1172-1182Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.