Isavuconazole Diffusion in Infected Human Brain.

Adult Aspergillosis / drug therapy Aspergillus fumigatus / drug effects Brain / microbiology Cerebrospinal Fluid Female Granulomatous Disease, Chronic / drug therapy Humans Magnetic Resonance Imaging Nitriles / therapeutic use Pyridines / therapeutic use Triazoles / therapeutic use Young Adult
cerebral aspergillosis isavuconazole pharmacokinetic therapeutic drug monitoring

Journal

Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061

Informations de publication

Date de publication:
10 2019
Historique:
received: 26 11 2018
accepted: 12 05 2019
pubmed: 14 8 2019
medline: 4 8 2020
entrez: 14 8 2019
Statut: epublish

Résumé

We report the cases of a 39-year-old woman with chronic lymphocytic leukemia and a 21-year-old man with chronic granulomatous disease treated for cerebral aspergillosis. The patients required radical surgery for infection progression despite adequate isavuconazole plasma concentration or neurological complication. We thus decided to measure the brain isavuconazole concentration. These results suggest that the concentrations of isavuconazole obtained in the infected brain tissue clearly differ from those obtained in the normal brain tissue and the cerebrospinal fluid.

Identifiants

DOI: 10.1128/AAC.02474-18 PMID: 31405852 PMC: PMC6761565
pubmed: 31405852
pii: AAC.02474-18
doi: 10.1128/AAC.02474-18
pmc: PMC6761565
pii:
doi:

Substances chimiques

Nitriles 0
Pyridines 0
Triazoles 0
isavuconazole 60UTO373KE

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2019 American Society for Microbiology.

Références

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Auteurs

Claire Rouzaud (C)

Necker-Enfants Malades University Hospital, Department of Infectious Diseases and Tropical Medicine, Centre d'Infectiologie Necker-Pasteur, Institut Imagine, AP-HP, Paris University, Paris, France.

Vincent Jullien (V)

Hôpital Européen Georges-Pompidou University Hospital, Department of Pharmacolgy, AP-HP, Paris University, Paris, France.

Anne Herbrecht (A)

Department of Neurosurgery, AP-HP, Bicêtre Hospital, Paris, France.

Bruno Palmier (B)

Faculté des Sciences Pharmaceutiques et Biologiques, EA4475-Pharmacologie de la Circulation Cérébrale, Paris University, Paris, France.

Simona Lapusan (S)

Department of Hematology and Cellular Therapy, AP-HP, Saint-Antoine Hospital, Paris, France.

Marjolaine Morgand (M)

Necker-Enfants Malades University Hospital, Department of Infectious Diseases and Tropical Medicine, Centre d'Infectiologie Necker-Pasteur, Institut Imagine, AP-HP, Paris University, Paris, France.

Romain Guéry (R)

Necker-Enfants Malades University Hospital, Department of Infectious Diseases and Tropical Medicine, Centre d'Infectiologie Necker-Pasteur, Institut Imagine, AP-HP, Paris University, Paris, France.

Amélie Dureault (A)

Necker-Enfants Malades University Hospital, Department of Infectious Diseases and Tropical Medicine, Centre d'Infectiologie Necker-Pasteur, Institut Imagine, AP-HP, Paris University, Paris, France.

François Danion (F)

Necker-Enfants Malades University Hospital, Department of Infectious Diseases and Tropical Medicine, Centre d'Infectiologie Necker-Pasteur, Institut Imagine, AP-HP, Paris University, Paris, France.

Stéphanie Puget (S)

Necker-Enfants Malades University Hospital, Department of Neurosurgery, AP-HP, Paris University, Paris, France.

Lauriane Goldwirt (L)

Hôpital Européen Georges-Pompidou University Hospital, Department of Pharmacolgy, AP-HP, Paris University, Paris, France.

Fanny Lanternier (F)

Necker-Enfants Malades University Hospital, Department of Infectious Diseases and Tropical Medicine, Centre d'Infectiologie Necker-Pasteur, Institut Imagine, AP-HP, Paris University, Paris, France.
Institut Pasteur, National Reference Center for Invasive Mycoses and Antifungals, Molecular Mycology Unit, CNRS UMR2000, Paris, France.

Olivier Lortholary (O)

Necker-Enfants Malades University Hospital, Department of Infectious Diseases and Tropical Medicine, Centre d'Infectiologie Necker-Pasteur, Institut Imagine, AP-HP, Paris University, Paris, France olivier.lortholary@aphp.fr.
Institut Pasteur, National Reference Center for Invasive Mycoses and Antifungals, Molecular Mycology Unit, CNRS UMR2000, Paris, France.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Isavuconazole Diffusion in Infected Human Brain.
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Mycoses › Aspergillose › Isavuconazole Diffusion in Infected Human Brain.
questionsmedicales.fr › Eucaryotes › Champignons › Deuteromycota › Aspergillus › Aspergillus fumigatus › Isavuconazole Diffusion in Infected Human Brain.
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Isavuconazole Diffusion in Infected Human Brain.
questionsmedicales.fr › Liquides et sécrétions biologiques › Liquides biologiques › Liquide extracellulaire › Liquide cérébrospinal › Isavuconazole Diffusion in Infected Human Brain.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Granulomatose septique chronique › Isavuconazole Diffusion in Infected Human Brain.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Isavuconazole Diffusion in Infected Human Brain.
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Isavuconazole Diffusion in Infected Human Brain.
questionsmedicales.fr › Composés chimiques organiques › Nitriles › Isavuconazole Diffusion in Infected Human Brain.
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Isavuconazole Diffusion in Infected Human Brain.
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Triazoles › Isavuconazole Diffusion in Infected Human Brain.
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Jeune adulte › Isavuconazole Diffusion in Infected Human Brain.