Female Sex and Brain-Selective Estrogen Benefit α-Synuclein Tetramerization and the PD-like Motor Syndrome in 3K Transgenic Mice.
DHED
estrogen
monomer
sex
tetramer
α-synuclein
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
18 09 2019
18 09 2019
Historique:
received:
07
02
2019
revised:
12
07
2019
accepted:
23
07
2019
pubmed:
14
8
2019
medline:
1
7
2020
entrez:
14
8
2019
Statut:
ppublish
Résumé
Many studies report a higher risk for Parkinson's disease (PD) and younger age of onset in men. This, and the fact that the neuropathological process underlying PD symptoms may begin before menopause, suggests that estrogen-based hormone therapy could modify this higher risk in males. However, the effects of female sex or estrogen on α-synuclein (αS) homeostasis and related PD neuropathology remain unknown. Here, we used an αS tetramer-abrogating mouse model of PD (3K) that amplifies the familial E46K PD mutation to investigate the effects of female sex and brain-selective estrogen treatment on αS tetramerization and solubility, formation of vesicle-rich αS
Identifiants
pubmed: 31405930
pii: JNEUROSCI.0313-19.2019
doi: 10.1523/JNEUROSCI.0313-19.2019
pmc: PMC6750939
doi:
Substances chimiques
Estrogens
0
alpha-Synuclein
0
Estradiol
4TI98Z838E
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7628-7640Subventions
Organisme : NINDS NIH HHS
ID : R01 NS109510
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS103123
Pays : United States
Informations de copyright
Copyright © 2019 the authors.
Références
Exp Neurol. 1999 Mar;156(1):138-48
pubmed: 10192785
Neurology. 1999 Jul 13;53(1):91-5
pubmed: 10408542
Neurology. 2000 Jun 27;54(12):2292-8
pubmed: 10881255
Neurology. 2000 Nov 14;55(9):1358-63
pubmed: 11087781
Nat Rev Neurosci. 2001 Jul;2(7):492-501
pubmed: 11433374
Brain Res Dev Brain Res. 2001 Aug 23;129(2):125-33
pubmed: 11506857
J Neurosci. 2002 May 1;22(9):3608-14
pubmed: 11978836
JAMA. 2002 Jul 17;288(3):321-33
pubmed: 12117397
J Neurobiol. 2003 Mar;54(4):638-47
pubmed: 12555275
Neuroscience. 2003;121(4):927-34
pubmed: 14580943
J Neuropathol Exp Neurol. 2003 Dec;62(12):1241-53
pubmed: 14692700
Neurology. 2004 Jun 8;62(11):2010-4
pubmed: 15184606
Neurotox Res. 2004;6(2):141-8
pubmed: 15325966
J Neurosci Res. 2005 Feb 1;79(3):279-86
pubmed: 15614791
Mov Disord. 2006 Dec;21(12):2211-4
pubmed: 17029261
Synapse. 2007 Jun;61(6):450-8
pubmed: 17372982
Clin Exp Pharmacol Physiol. 2007 Jul;34(7):555-65
pubmed: 17581209
J Neurosci. 2008 Mar 5;28(10):2471-84
pubmed: 18322092
Neurodegener Dis. 2008;5(3-4):257-60
pubmed: 18322406
PLoS One. 2008 Apr 09;3(4):e1974
pubmed: 18398484
J Neurochem. 2008 Sep;106(5):2143-57
pubmed: 18643794
Menopause. 2008 Nov-Dec;15(6):1169-75
pubmed: 18665039
J Neurol. 2008 Sep;255 Suppl 5:18-32
pubmed: 18787879
Horm Behav. 2010 Jan;57(1):23-34
pubmed: 19538962
Acta Neuropathol. 1977 Aug 16;39(2):173-5
pubmed: 197775
Pharmacol Rev. 2010 Jun;62(2):155-98
pubmed: 20392807
Nature. 2011 Aug 14;477(7362):107-10
pubmed: 21841800
PLoS One. 2011;6(8):e23939
pubmed: 21886844
Int J Alzheimers Dis. 2012;2012:258454
pubmed: 22548198
J Biol Chem. 2013 Mar 1;288(9):6371-85
pubmed: 23319586
Brain. 2013 Feb;136(Pt 2):412-32
pubmed: 23413261
PLoS One. 2013 Aug 27;8(8):e72428
pubmed: 24015243
PLoS One. 2013 Nov 20;8(11):e81314
pubmed: 24278419
Mol Cell Endocrinol. 2014 May 25;389(1-2):84-91
pubmed: 24508637
Restor Neurol Neurosci. 2014;32(4):447-62
pubmed: 24604006
Front Neuroendocrinol. 2014 Aug;35(3):370-84
pubmed: 24607323
Mov Disord. 2014 Nov;29(13):1631-6
pubmed: 25255692
Nat Commun. 2015 Jun 16;6:7314
pubmed: 26076669
Sci Transl Med. 2015 Jul 22;7(297):297ra113
pubmed: 26203081
Int J Endocrinol. 2015;2015:949085
pubmed: 26491443
Horm Behav. 2016 Jul;83:39-44
pubmed: 27210479
Mov Disord. 2016 Oct;31(10):1433-1443
pubmed: 27619535
Dev Psychobiol. 2017 Nov;59(7):863-875
pubmed: 28833057
Int J Dev Neurosci. 1987;5(2):91-8
pubmed: 2902739
Horm Behav. 2018 Feb;98:16-21
pubmed: 29183688
Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):798-803
pubmed: 29311330
Neuropharmacology. 2019 Mar 15;147:37-54
pubmed: 29649433
Chem Commun (Camb). 2018 Jul 17;54(58):8080-8083
pubmed: 29971274
Neuron. 2018 Oct 10;100(1):75-90.e5
pubmed: 30308173
Cell Rep. 2018 Dec 4;25(10):2742-2754.e31
pubmed: 30517862
Mol Cell. 2019 Mar 7;73(5):1001-1014.e8
pubmed: 30527540
J Neurosci. 2019 Apr 10;39(15):2792-2809
pubmed: 30728170
Neurology. 1988 Oct;38(10):1558-61
pubmed: 3419598
Acta Neuropathol. 1978 May 24;42(2):127-34
pubmed: 654884
Acta Neuropathol. 1993;85(4):445-8
pubmed: 8480516
J Neuropathol Exp Neurol. 1996 Mar;55(3):259-72
pubmed: 8786384