Myeloid maturation potentiates STAT3-mediated atypical IFN-γ signaling and upregulation of PD-1 ligands in AML and MDS.
Aged
B7-H1 Antigen
/ genetics
CD11b Antigen
/ genetics
Calcitriol
/ pharmacology
Cell Differentiation
/ drug effects
Cell Line, Tumor
Cell Proliferation
/ drug effects
Female
Gene Expression Regulation, Leukemic
HL-60 Cells
Humans
Interferon-gamma
/ immunology
Leukemia, Myeloid, Acute
/ genetics
Male
Middle Aged
Myelodysplastic Syndromes
/ genetics
Programmed Cell Death 1 Ligand 2 Protein
/ genetics
Rho Guanine Nucleotide Exchange Factors
/ genetics
Signal Transduction
THP-1 Cells
Tretinoin
/ pharmacology
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
12 08 2019
12 08 2019
Historique:
received:
17
01
2019
accepted:
01
08
2019
entrez:
14
8
2019
pubmed:
14
8
2019
medline:
27
10
2020
Statut:
epublish
Résumé
Interferon (IFN)-γ is the major mediator of anti-tumor immune responses; nevertheless, cancer cells use intrigue strategies to alter IFN-γ signaling and avoid elimination. Understanding the immune regulatory mechanisms employed by acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) cells upon exposure to IFN-γ is critical for development of immunotherapy and checkpoint blockade therapy approaches. This study aims to explore the influence of myeloid maturation on IFN-γ-induced PD-L1 and PD-L2 expression and on pro-leukemogenic transcription factor STAT3 signaling in AML and MDS. Stimulation of myeloid blasts' maturation by all-trans retinoic acid (ATRA) or 1α,25-dihydroxyvitamin D3 (vitamin D) increased the CD11b
Identifiants
pubmed: 31406210
doi: 10.1038/s41598-019-48256-4
pii: 10.1038/s41598-019-48256-4
pmc: PMC6691003
doi:
Substances chimiques
ARHGEF3 protein, human
0
B7-H1 Antigen
0
CD11b Antigen
0
CD274 protein, human
0
ITGAM protein, human
0
PDCD1LG2 protein, human
0
Programmed Cell Death 1 Ligand 2 Protein
0
Rho Guanine Nucleotide Exchange Factors
0
Tretinoin
5688UTC01R
Interferon-gamma
82115-62-6
Calcitriol
FXC9231JVH
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
11697Références
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