Worldwide human mitochondrial haplogroup distribution from urban sewage.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
12 08 2019
12 08 2019
Historique:
received:
19
02
2019
accepted:
17
07
2019
entrez:
14
8
2019
pubmed:
14
8
2019
medline:
11
11
2020
Statut:
epublish
Résumé
Community level genetic information can be essential to direct health measures and study demographic tendencies but is subject to considerable ethical and legal challenges. These concerns become less pronounced when analyzing urban sewage samples, which are ab ovo anonymous by their pooled nature. We were able to detect traces of the human mitochondrial DNA (mtDNA) in urban sewage samples and to estimate the distribution of human mtDNA haplogroups. An expectation maximization approach was used to determine mtDNA haplogroup mixture proportions for samples collected at each different geographic location. Our results show reasonable agreement with both previous studies of ancient evolution or migration and current US census data; and are also readily reproducible and highly robust. Our approach presents a promising alternative for sample collection in studies focusing on the ethnic and genetic composition of populations or diseases associated with different mtDNA haplogroups and genotypes.
Identifiants
pubmed: 31406241
doi: 10.1038/s41598-019-48093-5
pii: 10.1038/s41598-019-48093-5
pmc: PMC6690936
doi:
Substances chimiques
DNA, Mitochondrial
0
Sewage
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
11624Références
Bioinformatics. 2009 Jul 15;25(14):1754-60
pubmed: 19451168
Forensic Sci Int Genet. 2015 Jan;14:141-55
pubmed: 25450785
J Immunol Res. 2018 Feb 25;2018:3174868
pubmed: 29682588
Cancer Lett. 2007 May 8;249(2):249-55
pubmed: 17081685
Ann Surg Oncol. 2018 Jul;25(7):2027-2033
pubmed: 29725898
Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):11983-8
pubmed: 21730125
Nat Rev Genet. 2004 Aug;5(8):598-609
pubmed: 15266342
BMC Med Genet. 2009 Apr 21;10:35
pubmed: 19383124
BMJ. 1995 Apr 8;310(6984):890
pubmed: 7719171
Annu Rev Genet. 2007;41:539-64
pubmed: 18076332
Annu Rev Genet. 2017 Nov 27;51:241-263
pubmed: 28853921
Water Res. 2005 Feb;39(4):541-8
pubmed: 15707626
Bioinformatics. 2009 Jun 1;25(11):1422-3
pubmed: 19304878
Microb Cell Fact. 2016 Feb 15;15:37
pubmed: 26879378
Proc Natl Acad Sci U S A. 2018 Apr 3;115(14):3686-3691
pubmed: 29555771
Appl Transl Genom. 2016 Feb 01;8:23-30
pubmed: 27047756
Am J Hum Genet. 2000 Jan;66(1):262-78
pubmed: 10631156
Eur J Hum Genet. 2013 Dec;21(12):1423-8
pubmed: 23612573
Nature. 1987 Jan 1-7;325(6099):31-6
pubmed: 3025745
MMWR Surveill Summ. 2011 May 20;60(6):1-44
pubmed: 21597458
BMC Genomics. 2014 Jun 12;15:467
pubmed: 24923674
Mol Biol Evol. 1987 Jul;4(4):406-25
pubmed: 3447015
Mol Neurodegener. 2010 Feb 02;5:8
pubmed: 20181062
Pharmacogenomics. 2014 Nov;15(14):1771-1790
pubmed: 25493570
Forensic Sci Int Genet. 2017 Sep;30:93-105
pubmed: 28667863
BMC Genet. 2012 May 20;13:39
pubmed: 22606979
BMC Genet. 2001;2:13
pubmed: 11553319
mSystems. 2016 Oct 18;1(5):
pubmed: 27822556
Am J Hum Genet. 1995 Jul;57(1):133-49
pubmed: 7611282
Hum Mol Genet. 2016 Sep 15;25(18):4127-4142
pubmed: 27559109
AIDS. 2008 Nov 30;22(18):2429-39
pubmed: 19005266
Hum Mutat. 2009 Feb;30(2):E386-94
pubmed: 18853457
PLoS One. 2013 Apr 24;8(4):e62005
pubmed: 23637946
Am J Hum Genet. 1993 Sep;53(3):563-90
pubmed: 7688932
J Thorac Oncol. 2015 Feb;10(2):250-5
pubmed: 25376516
Nat Commun. 2019 Mar 8;10(1):1124
pubmed: 30850636
PLoS Genet. 2008 Aug 29;4(8):e1000167
pubmed: 18769715
Am J Hum Biol. 2008 Sep-Oct;20(5):584-91
pubmed: 18442080
J Urol. 2006 Feb;175(2):468-72; discussion 472-3
pubmed: 16406974
Eur J Hum Genet. 2004 Jun;12(6):495-504
pubmed: 14872198
Am J Hum Genet. 2010 Jun 11;86(6):904-17
pubmed: 20537299
Genetics. 1996 Dec;144(4):1835-50
pubmed: 8978068
Nucleic Acids Res. 2014 Jan;42(2):1111-6
pubmed: 24163253
Per Med. 2015;12(1):43-51
pubmed: 25601880
Science. 2007 Oct 19;318(5849):399-400
pubmed: 17947567
Nature. 2000 Dec 7;408(6813):708-13
pubmed: 11130070
Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):14205-10
pubmed: 25192939
Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):13039-13044
pubmed: 30478036
Nat Genet. 2003 Mar;33 Suppl:266-75
pubmed: 12610536
BMC Genomics. 2017 Feb 8;18(1):140
pubmed: 28178941
Perspect Health Inf Manag. 2014 Apr 01;11:1c
pubmed: 24808804
J Mol Evol. 1974;3(3):161-77
pubmed: 4368400
Curr Opin Obstet Gynecol. 2010 Feb;22(1):72-8
pubmed: 19841585
Bioinformatics. 2009 Aug 15;25(16):2078-9
pubmed: 19505943
Am J Hum Genet. 2010 May 14;86(5):661-73
pubmed: 20466090
Nat Genet. 1999 Oct;23(2):147
pubmed: 10508508
Am J Hum Genet. 2015 Feb 5;96(2):183-93
pubmed: 25620206
Genome Res. 2018 Sep;28(9):1255-1263
pubmed: 30076130