Imaging of glucose metabolism by 13C-MRI distinguishes pancreatic cancer subtypes in mice.
MRI
cancer biology
imaging
magnetic resonance spectroscopy
metabolism
metabolomics
mouse
tumor microenvironment
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
13 08 2019
13 08 2019
Historique:
received:
23
02
2019
accepted:
08
08
2019
pubmed:
14
8
2019
medline:
12
2
2020
entrez:
14
8
2019
Statut:
epublish
Résumé
Metabolic differences among and within tumors can be an important determinant in cancer treatment outcome. However, methods for determining these differences non-invasively in vivo is lacking. Using pancreatic ductal adenocarcinoma as a model, we demonstrate that tumor xenografts with a similar genetic background can be distinguished by their differing rates of the metabolism of 13C labeled glucose tracers, which can be imaged without hyperpolarization by using newly developed techniques for noise suppression. Using this method, cancer subtypes that appeared to have similar metabolic profiles based on steady state metabolic measurement can be distinguished from each other. The metabolic maps from 13C-glucose imaging localized lactate production and overall glucose metabolism to different regions of some tumors. Such tumor heterogeneity would not be not detectable in FDG-PET.
Identifiants
pubmed: 31408004
doi: 10.7554/eLife.46312
pii: 46312
pmc: PMC6706239
doi:
pii:
Substances chimiques
Carbon Isotopes
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : P30 CA177558
Pays : United States
Organisme : NCI NIH HHS
ID : 1ZIASC006321-39
Pays : United States
Organisme : NCI NIH HHS
ID : Intramural Research Program
Pays : United States
Déclaration de conflit d'intérêts
SK, JB, DC, SM, TS, NO, HM, PL, JM, KS, KY, PC, JM, AL, TF, WL, MK No competing interests declared, GR, AC, JA is affiliated with GE HealthCare. The author has no other competing interests to declare.
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