Evaluation of relaxant responses properties of cinnamon essential oil and its major component, cinnamaldehyde on human and rat corpus cavernosum.
Acrolein
/ analogs & derivatives
Aged
Analysis of Variance
Animals
Cinnamomum zeylanicum
/ chemistry
Erectile Dysfunction
/ drug therapy
Humans
Male
Middle Aged
Muscle Relaxation
/ drug effects
Oils, Volatile
/ pharmacology
Penile Erection
/ drug effects
Penis
/ drug effects
Phenylephrine
/ pharmacology
Phosphodiesterase 5 Inhibitors
/ pharmacology
Rats, Sprague-Dawley
Reproducibility of Results
Sildenafil Citrate
/ pharmacology
Vasoconstrictor Agents
/ pharmacology
Humans
Penile Induration
cinnamic aldehyde [Supplementary Concept]
Journal
International braz j urol : official journal of the Brazilian Society of Urology
ISSN: 1677-6119
Titre abrégé: Int Braz J Urol
Pays: Brazil
ID NLM: 101158091
Informations de publication
Date de publication:
Historique:
received:
07
01
2019
accepted:
20
04
2019
pubmed:
14
8
2019
medline:
2
11
2019
entrez:
14
8
2019
Statut:
ppublish
Résumé
Cinnamomum cassia (Cinnamon) is a well-known traditional medicine with therapeutic benefits for centuries. We evaluated the effects of cinnamon essential oil (CEO) and its main component cinnamaldehyde (CA) on human corpus cavernosum (HCC) and rat CC. The essential oil of cinnamon was analyzed for the confirmation of the oil profile. HCC specimens from patients undergoing penile prosthesis surgery (age 48-69 years) were utilized for functional studies. In addition, erectile responses in anesthetized control and diabetic rats were evaluated in vivo after intracavernosal injection of CEO and CA, and rat CC strips were placed in organ baths. After precontraction with phenylephrine (10μM), relaxant responses to CEO and CA were investigated. CA (96.9%) was found as the major component. The maximum relaxation responses to CEO and CA were 96.4±3.5% and 96.0±5.0% in HCC and 97.5±5.5% and 96.8±4.8% in rat CC, respectively. There was no difference between control and diabetic rats in relaxation responses to CEO and CA. The relaxant responses obtained with essential oil and CA were not attenuated in the presence of nitric oxide synthase (NOS) inhibitor, and soluble guanylate cyclase inhibitor (sGS) in CC. In vivo, erectile responses in diabetic rats were lower than in control rats, which was restored after intracavernosal injection of CEO and CA. CEO and CA improved erectile function and relaxation of isolated strips of rat CC and HCC by a NO/cGMP-independent mechanism. Further investigations are warranted to fully elucidate the restorative effects of CEO and CA on diabetic erectile dysfunction.
Identifiants
pubmed: 31408283
doi: 10.1590/S1677-5538.IBJU.2019.0016
pii: IBJU20190016
pmc: PMC6844336
doi:
Substances chimiques
Oils, Volatile
0
Phosphodiesterase 5 Inhibitors
0
Vasoconstrictor Agents
0
Phenylephrine
1WS297W6MV
Acrolein
7864XYD3JJ
Sildenafil Citrate
BW9B0ZE037
cinnamaldehyde
SR60A3XG0F
Types de publication
Evaluation Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1033-1042Informations de copyright
Copyright® by the International Brazilian Journal of Urology.
Déclaration de conflit d'intérêts
None declared.
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