Dendritic core-shell rhodium@platinum-cobalt nanocrystals for ultrasensitive electrochemical immunoassay of squamous cell carcinoma antigen.
Dendritic core-shell nanostructures
Electrochemical immunosensor
Squamous cell carcinoma antigen
Trimetallic nanocrystals
Journal
Journal of colloid and interface science
ISSN: 1095-7103
Titre abrégé: J Colloid Interface Sci
Pays: United States
ID NLM: 0043125
Informations de publication
Date de publication:
01 Nov 2019
01 Nov 2019
Historique:
received:
08
06
2019
revised:
02
08
2019
accepted:
03
08
2019
pubmed:
14
8
2019
medline:
14
2
2020
entrez:
14
8
2019
Statut:
ppublish
Résumé
Squamous cell carcinoma antigen (SCCA) has great diagnostic values for its high specificity (90-96%) in diagnosis of squamous cell carcinoma especially cancers, where electrochemical immunoassay is powerful for its accurate and reliable detection of specific tumor biomarkers at very low levels. In this work, well-defined three-dimensional dendritic core-shell rhodium@platinum-cobalt nanocrystals (Rh@PtCo NCs) were facilely prepared via a simple one-pot solvothermal strategy. Taking advantage of dramatically enhanced catalytic activity of the Rh@PtCo NCs for catechol oxidation, a label-free electrochemical immunosensor was developed for highly sensitive assay of SCCA. Under optimal conditions, the electrochemical signals were linearly correlated with the logarithm of the SCCA concentration, showing a broad linear range from 0.0001 to 10.0 ng mL
Identifiants
pubmed: 31408763
pii: S0021-9797(19)30913-0
doi: 10.1016/j.jcis.2019.08.012
pii:
doi:
Substances chimiques
Antigens, Neoplasm
0
Serpins
0
squamous cell carcinoma-related antigen
0
Cobalt
3G0H8C9362
Platinum
49DFR088MY
Rhodium
DMK383DSAC
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
647-654Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.