A paradigm shift in the intention-to-transplant children with biliary atresia: Outcomes of 101 cases and a review of the literature.
Kasai portoenterostomy
biliary atresia
centralization of care
children
innovative techniques
liver transplantation
living related donor
outcome research
referral practice
review
Journal
Pediatric transplantation
ISSN: 1399-3046
Titre abrégé: Pediatr Transplant
Pays: Denmark
ID NLM: 9802574
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
27
03
2019
revised:
14
07
2019
accepted:
23
07
2019
pubmed:
15
8
2019
medline:
20
9
2020
entrez:
15
8
2019
Statut:
ppublish
Résumé
For children with BA who do not benefit from Kasai surgery, the only therapeutic option is liver replacement and transplantation. The very decision to proceed for transplantation is a crucial point in time because it is the first step toward the preparation for the transplantation. The former time point is defined in this analysis as "intent-to-transplant" care pathway. In the life of every BA candidate for liver replacement, this point in time varies and mostly depends on the decision of their primary caring teams-about when to switch from supportive care to transplant, and thus to refer to a transplant center. This intent-to-transplant analysis of a series of 101 consecutive infants that were referred to a single transplant team showed that excellent overall outcome (97% survival) has been achieved overall. However, three deaths occurred that were clearly related to a late referral. This analysis and recent observations from other centers strongly support that the timing for referring these children to a transplant center and/or deciding to list them on the waiting list is currently too late and should be anticipated to what it is currently. This paradigm shift in the intention-to-transplant children is likely necessary for giving a better chance to an increased number of children and impacts positively on the general outcome. Networking and defining new tools for a rapid recognition of the infants who need early transplantation are necessary; centralization of these children may be helpful to achieve better outcomes than currently observed.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13569Informations de copyright
© 2019 Wiley Periodicals, Inc.
Références
Davenport M, Ville de Goyet J, Stringer MD, et al. Seamless management of biliary atresia. England & Wales 1999-2002. Lancet. 2004;363:1354-1357.
Kasahara M, Umeshita K, Sakamoto S, Fukuda A, Furukawa H, Uemoto S. Liver transplantation for biliary atresia: a systematic review. Pediatr Surg Int. 2017;33:1289-1295.
Nio M. Japanese Biliary Atresia Registry. Pediatr Surg Int Rev. 2017;33:1319-1325.
Pakarinen MP, Johansen LS, Svensson JF, et al. Outcomes of biliary atresia in the Nordic countries - a multicenter study of 158 patients during 2005-2016. J Pediatr Surg. 2018;53:1509-1515.
Chardot C, Buet C, Serinet MO, et al. Improving outcomes of biliary atresia: French national series 1986-2009. J Hepatol. 2013;58:1209-1217.
Davenport M, Ong E, Sharif K, et al. Biliary atresia in England and Wales: results of centralization and new benchmark. J Pediatr Surg. 2011;46:1689-1694.
Leung DH, Narang A, Minard CG, Hiremath G, Goss JA, Shepherd R. A 10-year United Network for Organ Sharing Review of mortality and risk factors in young children awaiting liver transplantation. Liver Transpl. 2016;22:1584-1592.
van der Doef H, van Rheenen PF, van Rosmalen M, Rogiers X, Verkade HJ; for Pediatric Liver Transplantation Centers of Eurotransplant. Wait-list mortality of young patients with biliary atresia: competing risk analysis of a Eurotransplant registry-based cohort. Liver Transpl. 2018;24:810-819.
Malenicka S, Ericzon BG, Jørgensen MH, et al. Impaired intention-to-treat survival after listing for liver transplantation in children with biliary atresia compared to other chronic liver diseases: 20 years' experience from the Nordic countries. Pediatr Transplant. 2017;21:e12851. Epub 2016 Dec 13.
de Vries W, de Langen ZJ, Aronson DC, et al. Mortality of biliary atresia in children not undergoing liver transplantation in The Netherlands. Pediatr Transplant. 2011;15:176-183.
de Ville de GoyetJ. Living donation for a paediatric liver transplantation: an opportunity to be used in accordance with ethical principles. MEDIC. 2015;23:39-51.
Miller CM, Durand F, Heimbach JK, et al. The International Liver Transplant Society Guideline on living liver donation. Transplantation. 2016;100:1238-1243.
Grimaldi C, di Francesco F, Chiusolo F, et al. Aggressive prevention and preemptive management of vascular complications after pediatric liver transplantation: a major impact on graft survival and long-term outcome. Pediatr Transplant. 2018;22:e13288.
Emond JC, de Ville de GoyetJ. Hepatic venous reconstruction as the stake of the liver: technical note and thoughts. Pediatr Transplant. 2014;18:420-422.
de Ville de Goyet J, di Francesco F, Sottani V, et al. Splitting livers: trans-hilar or transumbilical division? Technical aspects and comparative outcomes. Pediatr Transplant. 2015;19:517-526.
Kasahara M, de Ville de GoyetJ. Reducing left liver lobe grafts, more or less? Don't throw out the baby with the bath water. Pediatr Transplant. 2015;19:815-817.
Nadalin S, Monti L, Grimaldi C, di Francesco F, Tozzi AE, de Ville de Goyet J. Roux-en-Y hepatico-jejunostomy for a left segmental graft: do not twist the loop, stick it! Pediatr Transplant. 2015;19:358-365.
Angelico R, Trapani S, Spada Met al. A National Mandatory-Split Liver Policy: a report from the Italian Experience. Am J Transplant. 2019;12:2029-2043; Epub ahead of print.
McDiarmid SV, Anand R, Martz K, Millis MJ, Mazariegos G. A multivariate analysis of pre-, peri-, and post-transplant factors affecting outcome after pediatric liver transplantation. Ann Surg. 2011;254:145-154.
Broering DC, Kim JS, Mueller T, et al. One hundred thirty-two consecutive pediatric liver transplants without hospital mortality: lessons learned and outlook for the future. Ann Surg. 2004;240:1002-1012.
Englesbe MJ, Pelletier SJ, Kheterpal S, O'Reilly M, Campbell DA. A call for a national transplant surgical quality improvement program. Am J Transplant. 2006;6:666-670.
Englesbe MJ, Kelly B, Goss J, et al. Reducing pediatric liver transplant complications: a potential roadmap for transplant quality improvement initiatives within North America. Am J Transplant. 2012;12:2301-2306.
D'Souza R, Grammatikopoulos T, Pradhan A, et al. Acute-on-chronic liver failure in children with biliary atresia awaiting liver transplantation. Pediatr Transplant. 2019;23:e13339.
Kohaut J, Guérin F, Fouquet V, et al. First liver transplantation for biliary atresia in children: the hidden effects of non-centralization. Pediatr Transplant. 2018;22:e13232. [Epub ahead of print].
Karakoyun M, Baran M, Turan C, Kılıç M, Ergun O, Aydoğdu S. Infants with extrahepatic biliary atresia: effect of follow-up on the survival rate at Ege University Medical School transplantation center. Turk J Gastroenterol. 2017;28:298-302.
Lampela H, Ritvanen A, Kosola S, et al. National centralization of biliary atresia care to an assigned multidisciplinary team provides high-quality outcomes. Scand J Gastroenterol. 2012;47:99-107.
Durkin N, Davenport M. Centralization of Pediatric Surgical Procedures in the United Kingdom. Eur J Pediatr Surg. 2017;27:416-421.
McKiernan PJ, Baker AJ, Lloyd C, Mieli-Vergani G, Kelly DA. British paediatric surveillance unit study of biliary atresia: outcome at 13 years. J Pediatr Gastroenterol Nutr. 2009;48:78-81.
Sundaram SS, Mack CL, Feldman AG, Sokol RJ. Biliary atresia: Indications and timing of liver transplantation and optimization of pretransplant care. Liver Transpl. 2017;23:96-109.
Tessier ME, Harpavat S, Shepherd RW, et al. Beyond the Pediatric end-stage liver disease system: solutions for infants with biliary atresia requiring liver transplant. World J Gastroenterol. 2014;20:11062-11068.
Stringer MD. Biliary atresia: service delivery and outcomes. Semin Pediatr Surg. 2008;17:116-122.
Chardot C, Carton M, Spire-Bendelac N, et al. Is the Kasai operation still indicated in children older than 3 months diagnosed with biliary atresia? J Pediatr. 2001;138:224-228.
Superina R. Biliary atresia and liver transplantation: results and thoughts for primary liver transplantation in select patients. Pediatr Surg Int. 2017;33:1297-1304.
Wang P, Xun P, He K, Cai W. Comparison of liver transplantation outcomes in biliary atresia patients with and without prior portoenterostomy: a meta-analysis. Dig Liver Dis. 2016;48:347-352.
Kitajima T, Sakamoto S, Sasaki K, et al. Living donor liver transplantation for post-Kasai biliary atresia: analysis of pretransplant predictors of outcomes in infants. Liver Transpl. 2017;23:1199-1209.
Shneider BL, Magee JC, Karpen SJ, et al. Total serum bilirubin within 3 months of hepatoportoenterostomy predicts short-term outcomes in biliary atresia. J Pediatr. 2016;170:211-217.
Nakajima H, Koga H, Okawada M, Nakamura H, Lane GJ, Yamataka A. Does time taken to achieve jaundice-clearance influence survival of the native liver in post-Kasai biliary atresia? World J Pediatr. 2018;14:191-196.
Nightingale S, Stormon MO, O'Loughlin EV, et al. Early posthepatoportoenterostomy predictors of native liver survival in biliary atresia. J Pediatr Gastroenterol Nutr. 2017;64:203-209.
Hukkinen M, Kerola A, Lohi J, et al. Treatment policy and liver histopathology predict biliary atresia outcomes: results after National Centralization and Protocol Biopsies. J Am Coll Surg. 2018;226:46-57.
Pugliese R, Fonseca EA, Porta G, et al. Ascites and serum sodium are markers of increased waiting list mortality in children with chronic liver failure. Hepatology. 2014;59:1964-1971.
Bourdeaux C, Darwish A, Jamart J, et al. Living-related versus deceased donor pediatric liver transplantation: a multivariate analysis of technical and immunological complications in 235 recipients. Am J Transplant. 2007;7:440-447.
Montenovo MI, Bambha K, Reyes J, Dick A, Perkins J, Healey P. Living liver donation improves patient and graft survival in the pediatric population. Pediatr Transplant. 2019;23:e13318.
Mogul DB, Luo X, Bowring MG, et al. Fifteen-year trends in pediatric liver transplants: split, whole deceased, and living donor grafts. J Pediatr. 2018;196:148-153.
Austin MT, Feurer ID, Chari RS, Gorden DL, Wright JK, Pinson CW. Survival after pediatric liver transplantation: why does living donation offer an advantage? Arch Surg. 2005;140:465-470.
Emond J. Reducing complications in pediatric liver transplantation: do we have the answer? Am J Transplant. 2012;12:2267-2268.
Meyers RL, Tiao G, de Ville de Goyet J, Superina R, Aronson DC. Hepatoblastoma state of the art: pre-treatment extent of disease, surgical resection guidelines and the role of liver transplantation. Curr Opin Pediatr. 2014;26:29-36.
Kueht M, Thompson P, Rana A, Cotton R, O'Mahony C, Goss J. Effects of an early referral system on liver transplantation for hepatoblastoma at Texas Children's Hospital. Pediatr Transplant. 2016;20:515-522.
Ezekian B, Mulvihill MS, Schroder PM, et al. Improved contemporary outcomes of liver transplantation for pediatric hepatoblastoma and hepatocellular carcinoma. Pediatr Transplant. 2018;22:e13305.